Research Institute for Fragrance Materials, Inc., 50 Tice Boulevard, Woodcliff Lake, NJ 07677, USA.
Food Chem Toxicol. 2012 Oct;50 Suppl 3:S664-7. doi: 10.1016/j.fct.2012.03.016. Epub 2012 Mar 16.
A toxicologic and dermatologic review of 2-hydroxy-3,4-dimethyl-2-cyclopenten-1-one when used as a fragrance ingredient is presented. 2-Hydroxy-3,4-dimethyl-2-cyclopenten-1-one is a member of the fragrance structural group Ketones Cyclopentanones and Cyclopentenones. The common characteristic structural element of the group members is a cyclopentanone or cyclopentenone ring with a straight or branched chain alkane or alkene substituent. This review contains a detailed summary of all available toxicology and dermatology papers that are related to this individual fragrance ingredient and is not intended as a stand-alone document. Available data for 2-hydroxy-3,4-dimethyl-2-cyclopenten-1-one were evaluated, then summarized and includes physical properties data. A safety assessment of the entire Ketones Cyclopentanones and Cyclopentenones will be published simultaneously with this document; please refer to Belsito et al. (2012) for an overall assessment of the safe use of this material and all Ketones Cyclopentanones and Cyclopentenones in fragrances.
当 2-羟基-3,4-二甲基-2-环戊烯-1-酮用作香料成分时，对其进行了毒理学和皮肤学评估。2-羟基-3,4-二甲基-2-环戊烯-1-酮是香料结构基团酮类环戊酮和环戊烯酮的成员。该组成员的共同特征结构元素是具有直链或支链烷烃或烯烃取代基的环戊酮或环戊烯酮环。本综述包含了与该特定香料成分相关的所有可用毒理学和皮肤学论文的详细摘要，但不作为独立文件。对 2-羟基-3,4-二甲基-2-环戊烯-1-酮的可用数据进行了评估、总结，并包括物理性质数据。对整个酮类环戊酮和环戊烯酮的安全性评估将与本文件同时发布；请参阅 Belsito 等人（2012 年），以全面评估该材料以及香料中所有酮类环戊酮和环戊烯酮的安全使用情况。
