State Key Laboratory of Applied Organic Chemistry, College of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou 730000, People's Republic of China.
Steroids. 2012 Jun;77(7):811-8. doi: 10.1016/j.steroids.2012.03.003. Epub 2012 Mar 14.
Nine new highly oxygenated stigmastane-type steroids, vernoanthelcin A-I (1-9), and two new stigmastane-type steroidal glycosides, vernoantheloside A and B (10 and 11) were isolated from the aerial parts of Vernonia anthelmintica Willd. The structures of compounds 1-11 were determined on the basis of IR, MS, 1D-NMR, and 2D-NMR, and their absolute configurations were deduced using single-crystal X-ray diffraction and the CD exciton chirality method. Compounds 1, 5, 7, 9 and 10 were tested for their effects on estrogen biosynthesis in human ovarian granulosa-like cells (KGN cells).
从 Vernonia anthelmintica Willd 的地上部分分离得到了 9 种新型高度氧化的甾烷型甾体化合物，vernoanthelcin A-I（1-9），以及 2 种新型甾烷型甾体糖苷 vernoantheloside A 和 B（10 和 11）。基于 IR、MS、1D-NMR 和 2D-NMR，确定了化合物 1-11 的结构，并通过单晶 X 射线衍射和 CD 激子手性方法推导出它们的绝对构型。测试了化合物 1、5、7、9 和 10 对人卵巢颗粒状样细胞（KGN 细胞）中雌激素生物合成的影响。
