University of Michigan, Department of Anesthesiology, 24 Frank Lloyd Wright Drive, P.O. Box 385, Lobby M, Ann Arbor, MI 48106, United States.
Neurosci Lett. 2012 Jun 29;520(2):192-6. doi: 10.1016/j.neulet.2012.03.042. Epub 2012 Mar 22.
Proton magnetic resonance spectroscopy has been used extensively in the study of various neurobiological disorders: depression, schizophrenia, autism, etc. But its application to chronic pain is relatively new. Not many studies in chronic pain have used (1)H-MRS. The unique ability of (1)H-MRS to assess both static and dynamic levels of glutamate and γ-aminobutyric acid (GABA) gives this method a unique position in neuroscience. Emerging evidence in chronic pain suggests an elevated excitatory/inhibitory neurotransmitter ratio is present within brain regions involved in pain processing. The combination of (1)H-MRS imaging with pharmacologic interventions holds significant promise as a direct one-to-one matching of disease pathology with drug mechanism of action can be made. As such (1)H-MRS may be useful in discovery of novel compounds for chronic pain. Research in these areas may lead to improved diagnosis and treatment of these complex patients.
抑郁症、精神分裂症、自闭症等。但其在慢性疼痛中的应用相对较新。在慢性疼痛中，使用 (1)H-MRS 的研究并不多。(1)H-MRS 具有评估谷氨酸和γ-氨基丁酸 (GABA) 的静态和动态水平的独特能力，这使该方法在神经科学中具有独特的地位。慢性疼痛中出现的新证据表明，参与疼痛处理的脑区中存在兴奋性/抑制性神经递质比值升高的现象。(1)H-MRS 成像与药物干预相结合具有很大的潜力，因为可以直接将疾病病理学与药物作用机制一一对应。因此，(1)H-MRS 可能有助于发现治疗慢性疼痛的新型化合物。这些领域的研究可能会改善对这些复杂患者的诊断和治疗。
