DeltaQuest Foundation, Inc, Concord, MA 01742, USA.
Arch Phys Med Rehabil. 2012 Sep;93(9):1629-1636.e2. doi: 10.1016/j.apmr.2012.03.006. Epub 2012 Mar 21.
To further the development of the 99-item Symptom Inventory (SI) for multiple sclerosis (MS) using modern test theory methods to create 3 disability-specific short forms for MS patient subgroups identified using Performance Scale (PS) items.
A web-based cross-sectional study.
National MS Registry.
People with MS (N=1532) who participate in the North American Research Committee on Multiple Sclerosis Registry.
None.
The SI; the disease-specific PS and the Patient-Determined Disease Steps; and the generic Short-Form 12.
When the original SI subscales did not demonstrate unidimensionality, exploratory factor analysis was conducted yielding 14 factors that could be classified using the structure of the PS. Confirmatory factor analysis confirmed the unidimensionality of the hand function, vision, fatigue, cognitive, bowel/bladder, spasticity, and pain scales. The mobility scale was split into mobility and use of assistive devices; the sensory scale was split into sensory and vasomotor. Item response theory analyses revealed good model fit.
This study provides empirical support for a 10-scale symptom measure for use in MS clinical research, with short forms in 5 scales tailored to have good specificity for people with mild, moderate, and severe disability and single forms for the remaining 5 scales. The PS items can serve as a screener for these disability-specific short forms, which provide choice and flexibility that are similar to a computerized adaptive test but without the reliance on real-time computer infrastructure.
使用现代测试理论方法进一步开发 99 项多发性硬化症症状量表（SI），为使用绩效量表（PS）项目确定的多发性硬化症患者亚组创建 3 个特定残疾的简短形式。
一项基于网络的横断面研究。
国家多发性硬化症登记处。
参与北美多发性硬化症研究委员会登记处的多发性硬化症患者（N=1532）。
无。
SI；特定于疾病的 PS 和患者确定的疾病步骤；以及通用的简短形式 12。
当原始 SI 分量表没有表现出单维性时，进行了探索性因素分析，产生了 14 个因子，可以使用 PS 的结构进行分类。验证性因素分析证实了手功能、视力、疲劳、认知、肠/膀胱、痉挛和疼痛量表的单维性。运动功能量表分为运动功能和辅助设备使用；感觉量表分为感觉和血管运动。项目反应理论分析显示模型拟合良好。
这项研究为多发性硬化症临床研究提供了一种 10 分量表症状测量方法的实证支持，其中 5 个量表的简短形式针对轻度、中度和重度残疾人群具有良好的特异性，而其余 5 个量表则具有单一形式。PS 项目可作为这些特定残疾的简短形式的筛选器，提供类似于计算机自适应测试的选择和灵活性，但无需依赖实时计算机基础设施。
