Institute of Oncology "Prof. Dr. Ion Chiricuta" Cluj-Napoca, România.
Endocr J. 2012;59(6):489-96. doi: 10.1507/endocrj.ej11-0397. Epub 2012 Mar 23.
Thyroid carcinoma (TC) has an increasing incidence in the last decade and continues to represent the most frequent form of endocrine tumor. The aim of the study was to analyze the pediatric files of TC from the registry of "Prof. Dr. Ion Chiricuta" Institute of Oncology Cluj-Napoca, Romania (IOCN) and to provide the data related to the impact of nuclear fallout of Chernobyl on this pathology. We studied 72 children with TC treated between 1991 and 2010. The mean age was 15.3 years; the ratio female/male was 6.2:1. Twenty-nine children (40.2%) revealed metastasis in regional lymph nodes or lungs at the initial diagnostic. There were 63 differentiated thyroid carcinoma (DTC), 6 cases with medullary cancer (MC), 1 case with anaplastic carcinoma (AC), and 2 mixed cases. All patients underwent total thyroidectomy and the radioiodine was administered in 64 cases (activities between 1.1 - 28.1 GBq I-131). Fifty-two children (80.5%) are free of disease, 8 are in partial remission and 4 children are in evolution of the disease at minimum 12 months of follow-up. The incidence of TC was significantly increased 10 years after the accident. In the years after, the increasing trendline was stopped and at 25 years, the number of cases is stationary. The diagnosis of pediatric TC is made frequently in metastatic disease and the therapies must be conducted for many years till complete remission. A more clear strategy adapted to children is needed in the future.
甲状腺癌（TC）在过去十年中的发病率不断增加，并且仍然是最常见的内分泌肿瘤形式。本研究旨在分析罗马尼亚克卢日-纳波卡“Prof. Dr. Ion Chiricuta”肿瘤学研究所（IOCN）登记处的 TC 儿科病例，并提供与切尔诺贝利核沉降物对该病理学影响相关的数据。我们研究了 1991 年至 2010 年间治疗的 72 例 TC 儿童患者。平均年龄为 15.3 岁；女性/男性比例为 6.2:1。29 例患儿（40.2%）在初始诊断时即出现区域性淋巴结或肺部转移。有 63 例分化型甲状腺癌（DTC）、6 例甲状腺髓样癌（MC）、1 例间变性癌（AC）和 2 例混合癌。所有患者均接受了全甲状腺切除术，并在 64 例患者中进行了放射性碘治疗（I-131 活度为 1.1-28.1GBq）。52 例患儿（80.5%）无疾病，8 例部分缓解，4 例患儿在 12 个月的随访后疾病仍在进展。在事故发生 10 年后，TC 的发病率显著增加。此后，增长趋势线停止，25 年后，病例数量保持稳定。儿科 TC 的诊断通常在转移性疾病中进行，治疗必须持续多年，直至完全缓解。未来需要制定更适合儿童的明确策略。
