Markosyan T G, Alyaev Yu G, Glybochko P V, Kirpatovsky V I, Mudraya I S, Nikitin S S, Popov E G, Revenko S V
Department of Urology, I. M. Sechenov First Moscow State Medical University, Moscow, Russia.
Bull Exp Biol Med. 2011 Aug;151(4):405-10. doi: 10.1007/s10517-011-1342-8.
Small variations of electric impedance (bioimpedance) of human penis were examined in healthy volunteers and in patients with vascular erectile dysfunction (ED). The harmonic analysis revealed rhythmic oscillations of penile bioimpedance at frequencies corresponding to the heart and respiration rates and Mayer wave (0.1 Hz) and to multiple frequencies (harmonics) of the respiratory and cardiac oscillations. In normal penile bioimpedance spectrum, the Mayer and respiratory peaks were several times higher than the first cardiac (pulsatile) harmonic indicating neurogenic origin of rhythmic bioimpedance variations in the whole penis. The most of healthy individuals (78%) demonstrated the cardiac harmonics at the frequency range of 4-7 Hz that violated the monotone decrement of the pulsatile harmonic series suggesting the resonant character of oscillations of the penile arteries at this "near" frequency range. In contrast to stable 1-4 cardiac harmonics, the amplitudes of the near-range resonant harmonics could vary during few minutes suggesting a causal relation of the corresponding bioimpedance oscillations with the varying vascular tone in penile arteries. The most patients (89%) with vascular ED demonstrated not only the first 1-4 monotonically decrementing harmonics and the near-resonant ones, but also the stable cardiac harmonics at the "far" frequency range of 8-14 Hz that also disturbed the monotonic character of the cardiac harmonic series indicating the sclerotic alterations in regional arteries. In ED patients, insignificant decrease of the initial cardiac harmonics C1-C3 in comparison with the norm was accompanied by pronounced and significant decrease of the respiratory R1 and Mayer M1 peaks. The study showed that the far-frequency bioimpedance resonances at the range of 8-14 Hz and dramatic drop of Mayer and respiratory peaks are the diagnostic signs of vascular ED independent on the accompanying hormonal or neurogenic disorders.
在健康志愿者和患有血管性勃起功能障碍（ED）的患者中，对人体阴茎的电阻抗（生物阻抗）微小变化进行了检测。谐波分析显示，阴茎生物阻抗在与心率、呼吸频率以及迈尔波（0.1赫兹）相对应的频率处，以及在呼吸和心脏振荡的多个频率（谐波）处存在节律性振荡。在正常阴茎生物阻抗谱中，迈尔波和呼吸峰比第一心脏（搏动性）谐波高几倍，这表明整个阴茎的节律性生物阻抗变化具有神经源性起源。大多数健康个体（78%）在4 - 7赫兹频率范围内表现出心脏谐波，这打破了搏动性谐波系列的单调递减，表明在此“近”频率范围内阴茎动脉振荡具有共振特征。与稳定的1 - 4个心脏谐波不同，近程共振谐波的振幅在几分钟内可能会发生变化，这表明相应的生物阻抗振荡与阴茎动脉血管张力变化之间存在因果关系。大多数患有血管性ED的患者（89%）不仅表现出最初的1 - 4个单调递减谐波和近共振谐波，还表现出在8 - 14赫兹“远”频率范围内的稳定心脏谐波，这也扰乱了心脏谐波系列的单调特征，表明局部动脉存在硬化改变。在ED患者中，与正常情况相比，最初的心脏谐波C1 - C3略有下降，同时呼吸R1峰和迈尔波M1峰显著下降。该研究表明，8 - 14赫兹范围内的远频生物阻抗共振以及迈尔波和呼吸峰的显著下降是血管性ED的诊断标志，与伴随的激素或神经源性疾病无关。
