Laboratory of General Pathology of Cardiorespiratory System, Research Institute of General Pathology and Pathophysiology, Moscow, Russia.
Department of Bioengineering Technologies and Support of Research, Moscow, Russia.
Bull Exp Biol Med. 2021 Apr;170(6):719-723. doi: 10.1007/s10517-021-05140-4. Epub 2021 Apr 24.
The experiments on narcotized male rats (n=30) determined the parameters of passive and active pulsatile modes of isolated segment of femoral artery in situ. Rheographic elasticity (RE) and reactivity (RR) were correspondingly determined as the ratios of peak-to-peak (p2p) magnitudes of passive and active pulsatile oscillations of arterial electroimpedance (AEI) to p2p magnitude of BP undulations. The medians and interquartile ranges of RE and RR were 6 (3; 11) and 70 (40; 110) mΩ/mm Hg, respectively. The maximal and minimal values of RE and RR in various rats differed by 50 and 80 times, respectively, and were bimodally distributed: in major group (n=23), the values were RE<15 and RR<200 mΩ/mm Hg, whereas in minor group (n=7), these parameters were RE>20 and RR>300 mΩ/mm Hg. The above ranges of RE and RR parameters were considered as the diagnostic signs of normal and pseudo-healthy rats with pathologically augmented AEI oscillations, respectively. Statistical analysis of all rats (n=30) revealed the positive correlation between RE and RR (r=0.76) with linear regression RR=31+7.6×RE. It is hypothesized that this correlation is underlain by a mechanism similar to that described by the Frank-Starling law for myocardium.
在麻醉雄性大鼠（n=30）的实验中，确定了原位分离股动脉节段的被动和主动脉动模式的参数。相应地，作为动脉电阻抗（AEI）被动和主动脉动振荡的峰峰值（p2p）幅度与 BP 波动的 p2p幅度之比，确定了血流动力弹性（RE）和反应性（RR）。RE 和 RR 的中位数和四分位间距分别为 6（3；11）和 70（40；110）mΩ / mmHg。不同大鼠的 RE 和 RR 的最大值和最小值相差 50 倍和 80 倍，呈双峰分布：在主要组（n=23）中，RE<15 和 RR<200 mΩ / mmHg，而在次要组（n=7）中，这些参数为 RE>20 和 RR>300 mΩ / mmHg。RE 和 RR 参数的上述范围分别被认为是病理性增强 AEI 振荡的正常和假性健康大鼠的诊断标志。对所有大鼠（n=30）的统计分析显示，RE 和 RR 之间存在正相关（r=0.76），线性回归 RR=31+7.6×RE。据推测，这种相关性是由类似于心肌的 Frank-Starling 定律描述的机制引起的。
