Brodsky M C, Glasier C M, Pollock S C, Angtuago E J
Department of Ophthalmology, University of Arkansas for Medical Sciences, Little Rock.
Arch Ophthalmol. 1990 Nov;108(11):1562-7. doi: 10.1001/archopht.1990.01070130064032.
High-resolution magnetic resonance images of the intracranial optic nerves and chiasm were obtained in 15 patients with severe optic nerve hypoplasia. These were compared, in a double-blind manner, with similar images from 30 age-matched controls. On both coronal and sagittal images, hypoplastic optic nerves were thin and demonstrated signal attenuation when compared with normal optic nerves. All patients with severe bilateral optic nerve hypoplasia also had diffuse chiasmal hypoplasia, which was seen best on coronal images. Patients with unilateral or asymmetrical optic nerve hypoplasia had variable chiasmal abnormalities. The degree to which the magnetic resonance diagnosis of optic nerve hypoplasia matched the clinical diagnosis was highly significant (P less than .001, Fisher's Exact Test) for both coronal and sagittal views of the intracranial optic nerves. Oblique axial and coronal views of the orbital optic nerves did not reliably distinguish optic nerve hypoplasia from normal optic nerves. High-resolution magnetic resonance imaging is a useful diagnostic modality to identify small optic nerves neuroradiologically.
对15例严重视神经发育不全患者进行了颅内视神经和视交叉的高分辨率磁共振成像检查。将这些图像与30例年龄匹配的对照者的类似图像进行双盲比较。在冠状面和矢状面上，发育不全的视神经均较细，与正常视神经相比表现为信号衰减。所有严重双侧视神经发育不全的患者也都有弥漫性视交叉发育不全，在冠状面上显示最佳。单侧或不对称视神经发育不全的患者有不同的视交叉异常。对于颅内视神经的冠状面和矢状面视图，磁共振对视神经发育不全的诊断与临床诊断的匹配程度非常显著（P<0.001，Fisher精确检验）。眼眶视神经的斜轴位和冠状面视图不能可靠地区分发育不全的视神经与正常视神经。高分辨率磁共振成像是一种有用的诊断方法，可通过神经放射学识别细小的视神经。
