Skopp Gisela, Zimmer Gisela
Institut für Rechtsmedizin und Verkehrsmedizin am Universitätsklinikum Heidelberg.
Arch Kriminol. 2012 Jan-Feb;229(1-2):44-54.
A case of pregabalin misuse associated with delusional ideas in a drug addict is reported. Pregabalin has been approved as an adjunct therapy for epilepsy, but also for neuropathic pain and generalized anxiety disorders and is widely used today. It has also been used in clinical trials to study its potential utility as a treatment for tobacco, alcohol and benzodiazepine addiction. Web sites, case reports and an epidemiological study (Swedish National Register of Adverse Drug Reactions) suggest that the drug may be abused, especially by substance-dependent individuals. Pregabalin was analyzed by LC/MS/MS following precipitation of serum proteins. Vigabatrin was used as internal standard. The concentration of 25 pg pregabalin/mL serum determined in the present case is the second highest value published so far after misuse of the substance. Due to paradoxical agitation, anxiety attacks and abnormal thinking, the man was exculpated. Further studies are required to assess the actual abuse potential of pregabalin.
报告了1例与妄想观念相关的普瑞巴林滥用病例，患者为一名吸毒成瘾者。普瑞巴林已被批准作为癫痫的辅助治疗药物，也用于治疗神经性疼痛和广泛性焦虑症，如今被广泛使用。它还被用于临床试验，以研究其作为烟草、酒精和苯二氮卓类药物成瘾治疗方法的潜在效用。网站、病例报告和一项流行病学研究（瑞典国家药物不良反应登记处）表明，该药物可能会被滥用，尤其是物质依赖者。血清蛋白沉淀后，采用液相色谱-串联质谱法（LC/MS/MS）分析普瑞巴林。以vigabatrin作为内标。本病例中测定的血清普瑞巴林浓度为25 pg/mL，是该物质滥用后迄今为止公布的第二高值。由于出现了矛盾性激越、焦虑发作和思维异常，该男子被免予起诉。需要进一步研究以评估普瑞巴林实际的滥用可能性。
