Department of Pathology, Massachusetts General Hospital and Harvard Medical School, 55 Fruit Street, Boston, MA 02114, USA.
Nat Rev Nephrol. 2012 Mar 27;8(5):255-7. doi: 10.1038/nrneph.2012.61.
Measurement of glomerular and peritubular capillaritis in kidney transplant biopsy samples identifies allograft dysfunction associated with alloantibodies. Sis et al. show that this technique has a higher sensitivity but lower specificity than the current diagnostic criteria using peritubular capillary C4d deposition, and that capillaritis is an independent predictor of progression to graft failure.
在肾移植活检样本中测量肾小球和肾小管毛细血管炎可识别与同种抗体相关的移植物功能障碍。Sis 等人表明，与目前使用肾小管毛细血管 C4d 沉积的诊断标准相比，该技术具有更高的敏感性和较低的特异性，并且毛细血管炎是移植物衰竭进展的独立预测因子。
