Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, New Territories, Hong Kong SAR,
Calcif Tissue Int. 2012 May;90(5):396-403. doi: 10.1007/s00223-012-9586-5. Epub 2012 Mar 27.
Data on the association between dietary vitamin K intake and fracture risk are limited among Chinese. This study examined such an association in community-dwelling elderly in Hong Kong. We present data from 2,944 subjects (1,605 men, 1,339 women) who participated in a prospective cohort study. Baseline dietary intakes of energy, protein, calcium, vitamin D, and vitamin K were assessed using a food-frequency questionnaire. Data on incident hip fracture and nonvertebral fracture during a median of 6.9 follow-up years were collected from a hospital database. Cox regression analyses were performed with adjustments for age, education attainment, smoking status, alcohol use, body mass index, hip bone mineral density, physical activity, use of calcium supplement, and energy-adjusted nutrient intakes. There were 29 (1.8 %) men and 19 (1.4 %) women with incident hip fractures and 97 (6.0 %) men and 88 (6.6 %) women with nonvertebral fractures. The median (interquartile range) of dietary vitamin K intake was 241.8 (157.5-360.8) and 238.9 (162.4-343.6) μg/day in men and women, respectively. Similar dietary vitamin K intakes were observed between subjects with hip or nonvertebral fractures and subjects without hip or nonvertebral fractures. In both men and women, dietary vitamin K intake was not associated with fracture risks at all measured sites in either crude or adjusted models. In Chinese community-dwelling elderly, hip or nonvertebral fracture risk was not associated with dietary vitamin K intake. The high dietary vitamin K intake of the studied group may have limited the ability to detect the association between vitamin K intake and fracture risk.
关于饮食维生素 K 摄入与骨折风险之间的关系，中国的数据有限。本研究在香港的社区居住的老年人中对此进行了研究。我们展示了 2944 名参与者（1605 名男性，1339 名女性）的数据，这些参与者参加了一项前瞻性队列研究。使用食物频率问卷评估了基线的能量、蛋白质、钙、维生素 D 和维生素 K 的饮食摄入量。通过医院数据库收集了中位数为 6.9 年的随访期间发生髋部骨折和非椎体骨折的数据。使用 Cox 回归分析进行了调整，调整因素包括年龄、教育程度、吸烟状况、饮酒情况、体重指数、髋部骨矿物质密度、身体活动、钙补充剂的使用以及能量调整后的营养素摄入量。有 29 名（1.8%）男性和 19 名（1.4%）女性发生髋部骨折，97 名（6.0%）男性和 88 名（6.6%）女性发生非椎体骨折。男性和女性的饮食维生素 K 摄入量中位数（四分位距）分别为 241.8（157.5-360.8）和 238.9（162.4-343.6）μg/天。髋部或非椎体骨折的患者和髋部或非椎体骨折的患者之间观察到相似的饮食维生素 K 摄入量。在男性和女性中，在未经调整和调整的模型中，饮食维生素 K 摄入量均与所有测量部位的骨折风险无关。在中国社区居住的老年人中，髋部或非椎体骨折的风险与饮食维生素 K 摄入量无关。研究组的高饮食维生素 K 摄入量可能限制了检测维生素 K 摄入量与骨折风险之间关系的能力。
