长期微重力暴露对大鼠比目鱼肌纤维细胞呼吸的影响。

Effects of long-term microgravitation exposure on cell respiration of the rat musculus soleus fibers.

作者信息

Veselova O M, Ogneva I V, Larina I M

机构信息

Institute of Biomedical Problems, the Russian Academy of Sciences, Moscow, Russia.

出版信息

Bull Exp Biol Med. 2011 Jul;151(3):318-20. doi: 10.1007/s10517-011-1319-7.

DOI:10.1007/s10517-011-1319-7

PMID:22451876

Abstract

Cell respiration of the m. soleus fibers was studied in Wistar rats treated with succinic acid and exposed to microgravitation for 35 days. The results indicated that respiration rates during utilization of endogenous and exogenous substrates and the maximum respiration rate decreased in animals subjected to microgravitation without succinate treatment. The respiration rate during utilization of exogenous substrate did not increase in comparison with that on endogenous substrates. Succinic acid prevented the decrease in respiration rate on endogenous substrates and the maximum respiration rate. On the other hand, the respiration rate on exogenous substrates was reduced in vivarium control rats receiving succinate in comparison with intact control group. That could indicate changed efficiency of complex I of the respiratory chain due to reciprocal regulation of the tricarbonic acid cycle.

摘要

在经琥珀酸处理并暴露于微重力环境35天的Wistar大鼠中，研究了比目鱼肌纤维的细胞呼吸。结果表明，在未用琥珀酸盐处理而处于微重力环境的动物中，内源性和外源性底物利用过程中的呼吸速率以及最大呼吸速率均降低。与内源性底物相比，外源性底物利用过程中的呼吸速率并未增加。琥珀酸可防止内源性底物呼吸速率和最大呼吸速率的降低。另一方面，与完整对照组相比，在饲养对照大鼠中接受琥珀酸盐后，外源性底物的呼吸速率降低。这可能表明由于三羧酸循环的相互调节，呼吸链复合体I的效率发生了变化。