Vrzheshch P V, Verkhusha V V, Varfolomeev S D
Biofizika. 1990 Jul-Aug;35(4):637-41.
A platelet aggregation model in shear flow taking into account the kinetics of intercellular fibrinogen bond formation limited by aggregated platelets rotation time was considered. For this consideration the average duration of platelets interaction in flow with shear rate value G is shown to be pi/4G. One fibrinogen bond is sufficient to form a solid aggregate between two platelets. The equation for single platelets disappearance rate concerned with intercellular fibrinogen bond formation, stochastic character of bond distribution in collided platelets and hydrodynamically controlled interaction time was obtained. The Hill's approximation for the obtained aggregation rate dependences was suggested and appropriate constants were determined. The qualitative criterion of platelets aggregating systems behavior was introduced.
考虑了一种剪切流中的血小板聚集模型，该模型考虑了受聚集血小板旋转时间限制的细胞间纤维蛋白原键形成动力学。基于此考虑，在剪切速率值为G的流动中，血小板相互作用的平均持续时间为π/4G。一个纤维蛋白原键足以在两个血小板之间形成固体聚集体。得到了与细胞间纤维蛋白原键形成、碰撞血小板中键分布的随机特性以及流体动力学控制的相互作用时间相关的单个血小板消失率方程。提出了所得聚集速率依赖性的希尔近似，并确定了适当的常数。引入了血小板聚集系统行为的定性标准。
