Unit for Drug Research and Development, North-West University, Potchefstroom, South Africa.
Curr Drug Deliv. 2012 May;9(3):297-304. doi: 10.2174/156720112800389115.
Aloe vera gel previously showed the ability to increase the bioavailability of vitamins and to enhance the in vitro transport of a macromolecular drug across intestinal epithelial cell monolayers. The purpose of this study is to investigate the potential of other species of aloe to act as drug absorption enhancement agents. The effect of gel materials from three South African aloes; Aloe ferox, A. marlothii and A. speciosa on the transepithelial electrical resistance and permeability of atenolol across excised intestinal tissue of the rat as well as the transport of FITC-dextran across Caco-2 cell monolayers was investigated. The aloe gel materials exhibited the ability to statistically significantly reduce the transepithelial electrical resistance of excised rat intestinal tissue but did not significantly increase the transport of atenolol across this in vitro tissue model at the concentrations tested. At least one concentration of each aloe gel material enhanced the transport of FITC-dextran statistically significantly across Caco-2 cell monolayers. The aloe gel materials showed potential to act as drug absorption enhancing agents across intestinal epithelia. The absorption enhancement effect was dependent on the type of in vitro model and type of drug was investigated.
库拉索芦荟凝胶先前显示出增加维生素生物利用度和增强大分子药物在肠上皮细胞单层中的体外转运的能力。本研究的目的是研究其他种类的芦荟作为药物吸收增强剂的潜力。三种南非芦荟（Aloe ferox、A. marlothii 和 A. speciosa）的凝胶材料对酮康唑透过大鼠离体肠组织的跨上皮电阻和通透性以及 FITC-葡聚糖透过 Caco-2 细胞单层的转运的影响进行了研究。芦荟凝胶材料表现出降低离体大鼠肠组织跨上皮电阻的能力，但在测试浓度下，酮康唑透过这种体外组织模型的转运没有显著增加。至少一种浓度的每种芦荟凝胶材料都显著增强了 FITC-葡聚糖在 Caco-2 细胞单层中的转运。芦荟凝胶材料显示出作为肠上皮细胞药物吸收增强剂的潜力。吸收增强效应取决于体外模型的类型和药物的类型。
