Centre for Advanced Studies in Botany, University of Madras, Chennai, India.
Clin Exp Dermatol. 2012 Jun;37(4):418-24. doi: 10.1111/j.1365-2230.2011.04285.x. Epub 2012 Mar 27.
Wound healing occurs as a fundamental response to tissue injury. Several natural products have been shown to accelerate the healing process.
To observe the efficacy of topical administration of an ethanolic extract of Ageratum conyzoides on cutaneous wound healing in rats.
An ethanolic extract of A. conyzoides was prepared, and its wound-healing efficacy on rats was studied. An open excision wound was made on the back of each rat, and 200 μL (40 mg/kg body weight) of the A. conyzoides extract was applied topically once daily to the treated wounds. The control wounds were treated with 200 μL of 50% ethanol. The wound tissues formed were removed at 4, 8 and 12 days after wounding, and biochemical parameters such as DNA, total protein, total collagen, hexosamine and uronic acid were estimated. The extent of epithelialization and the tensile strength of the wounded tissues were also measured.
The A. conyzoides extract increased cellular proliferation and collagen synthesis. Wounds treated with the extract were found to heal much faster, based on the improved rates of epithelialization and wound contraction, and on the histopathological results. A 40% increase in the tensile strength of the treated tissue was seen.
Topical application of A. conyzoides accelerates the rate of wound healing.
伤口愈合是组织损伤的基本反应。已经有几种天然产物被证明可以加速愈合过程。
观察苍耳草乙醇提取物局部给药对大鼠皮肤伤口愈合的疗效。
制备苍耳草乙醇提取物，并研究其对大鼠的伤口愈合作用。在每只大鼠的背部制造一个开放性切除伤口，每天一次将 200μL（40mg/kg 体重）的苍耳草提取物局部应用于处理过的伤口。对照伤口用 200μL 的 50%乙醇处理。在受伤后 4、8 和 12 天去除形成的伤口组织，并估计 DNA、总蛋白、总胶原、己糖胺和糖醛酸等生化参数。还测量了上皮化程度和受伤组织的拉伸强度。
苍耳草提取物增加了细胞增殖和胶原合成。基于上皮化和伤口收缩的改善率以及组织病理学结果，用提取物处理的伤口愈合得更快。处理组织的拉伸强度增加了 40%。
苍耳草的局部应用加速了伤口愈合的速度。
