Lin Kou Burn Centre, the Department of Plastic and Reconstructive Surgery, Chang Gung Memorial Hospital, Chang Gung Medical College and Chang Gung University, Taipei, Taiwan.
J Eur Acad Dermatol Venereol. 2013 May;27(5):628-33. doi: 10.1111/j.1468-3083.2012.04502.x. Epub 2012 Mar 27.
Toxic epidermal necrolysis syndrome (TEN) is a rare, life-threatening, drug-related skin reaction with a high mortality rate. To date, only a few studies with insufficient sample sizes have been conducted to analyse SCORTEN in Asian populations with TEN.
To analyse SCORTEN and other related factors that affect TEN patients in Taiwan.
A retrospective review of medical records of 101 patients with TEN from 1992 to 2009.
There were 62 cases of adverse reactions to a single medication and 39 cases of idiopathic reaction, from multiple medications, or infectious pathogens, of 101 TEN patients. Of the seven individual SCORTEN parameters, only associate malignancy, detached or compromised body surface area >10%, serum urea and bicarbonate were statistically significant in the multivariate analysis. Factors such as 1.5 times baseline serum creatinine levels, urine output of less than 0.5 mL/kg for 6 h and acute renal failure were connected with subsequent mortality.
The SCORTEN score is effective in predicting the outcome in Taiwanese TEN patients. A number of factors are predictors of mortality. In our study, we determine renal insufficiency and failure to be a marker for predicting a poor outcome.
中毒性表皮坏死松解症（TEN）是一种罕见的、危及生命的、与药物相关的皮肤反应，死亡率很高。迄今为止，仅有少数样本量不足的研究对亚洲 TEN 人群中的 SCORTEN 进行了分析。
分析 SCORTEN 及其他影响台湾 TEN 患者的相关因素。
回顾性分析了 1992 年至 2009 年间 101 例 TEN 患者的病历。
101 例 TEN 患者中，有 62 例为单一药物不良反应，39 例为多药、特发性反应或感染病原体。在 7 个 SCORTEN 个体参数中，仅相关恶性肿瘤、分离或受损体表面积>10%、血清尿素和碳酸氢盐在多变量分析中有统计学意义。血清肌酐水平升高 1.5 倍、6 小时内尿量<0.5ml/kg 和急性肾衰竭等因素与随后的死亡率有关。
SCORTEN 评分可有效预测台湾 TEN 患者的结局。有许多因素是死亡的预测指标。在我们的研究中，我们确定肾功能不全和衰竭是预测不良预后的标志物。
