Galvani D W, Cawley J C
University Department of Haematology, Royal Liverpool Hospital, UK.
Blood Rev. 1990 Sep;4(3):175-80. doi: 10.1016/0268-960x(90)90045-t.
Interferon-alpha (IFN alpha) has been extensively studied, both in clinical trials and in the laboratory. The cytokine has proved most effective in haemic malignancy, in particular hairy cell and chronic granulocytic leukaemia. This article deals with the current status of IFN alpha in these conditions and the possible basis of this sensitivity. Other less responsive haemic malignancies are also discussed.
α干扰素（IFNα）在临床试验和实验室中都得到了广泛研究。这种细胞因子在血液系统恶性肿瘤中已被证明最为有效，尤其是毛细胞白血病和慢性粒细胞白血病。本文论述了α干扰素在这些病症中的现状以及产生这种敏感性的可能原因。还讨论了其他反应较差的血液系统恶性肿瘤。
