Baer M R, Ozer H, Foon K A
Division of Hematologic Oncology, Roswell Park Cancer Institute, Buffalo, New York 14263.
Br J Haematol. 1992 Jun;81(2):167-9. doi: 10.1111/j.1365-2141.1992.tb08202.x.
Interferon-alpha is an effective agent in the treatment of chronic myelogenous leukaemia and hairy cell leukaemia. Because interferon-alpha does not inhibit DNA synthesis, we have used it to treat these diseases during pregnancy. We report here two patients with chronic myelogenous leukaemia and two patients with hairy cell leukaemia managed with interferon-alpha during pregnancy. Interferon-alpha was well tolerated, and the pregnancies proceeded without complications. All four infants were apparently normal at birth, and all four have enjoyed normal growth and development. Interferon-alpha may represent relatively safe therapy during pregnancy, because of its lack of inhibition of DNA synthesis. Nevertheless, recommendations regarding the use of interferon-alpha to treat chronic leukaemias during pregnancy must await further experience with this agent in this setting.
α干扰素是治疗慢性粒细胞白血病和毛细胞白血病的有效药物。由于α干扰素不抑制DNA合成，我们已将其用于治疗孕期的这些疾病。我们在此报告两例慢性粒细胞白血病患者和两例毛细胞白血病患者在孕期接受α干扰素治疗的情况。α干扰素耐受性良好，妊娠过程无并发症。所有四名婴儿出生时显然正常，且均正常生长发育。由于α干扰素缺乏对DNA合成的抑制作用，它可能是孕期相对安全的治疗方法。然而，关于孕期使用α干扰素治疗慢性白血病的建议，必须等待在此情况下对该药物有更多经验之后再作决定。
