Casali Institute of Applied Chemistry, Center for Nanoscience and Nanotechnology, The Hebrew University of Jerusalem, Jerusalem 91904, Israel.
Langmuir. 2012 May 1;28(17):6978-84. doi: 10.1021/la204741f. Epub 2012 Apr 19.
This study presents a method for one-step formation of poly(ethylene oxide) nanofibers incorporating nanoparticles of a poorly water-soluble compound. Using the new method reported here, nanofiber-nanoparticle composites are fabricated in one step by electrospinning of an oil-in-water microemulsion, in which a model material, propylparaben, has been dissolved within the volatile dispersed phase in the presence of a high-molecular-weight polymer. The approach is based on nanoscale confinement to the dispersed phase of an oil-in-water microemulsion with a volatile oil phase, in which the poorly water-soluble materials are dissolved. Thus, when the thermodynamically stable oil-in-water microemulsion is combined with the rapid evaporation of solvent inherent in the electrospinning process, the droplets are converted into organic nanoparticles embedded within a polymeric nanofiber. In addition to possessing process simplicity, this method exhibits a very high percentage of nanoparticle loading with desirable active material properties. Specifically, the diameter of the nanofibers is in the range of 60-185 nm, and propylparaben exists within the nanofiber as nanocrystals of 30-120 nm. These dimensions suggest that the nanofiber-nanocrystal composites could serve as a delivery system for water-insoluble materials.
本研究提出了一种一步法制备包含纳米颗粒的聚环氧乙烷纳米纤维的方法，该纳米颗粒为水溶性差的化合物。使用这里报道的新方法，通过油包水微乳液的静电纺丝一步制备了纳米纤维-纳米颗粒复合材料，其中模型材料对羟基苯甲酸丙酯在挥发性分散相中溶解在高分子量聚合物的存在下。该方法基于纳米级限制在具有挥发性油相的油包水微乳液的分散相中，其中难溶于水的材料溶解。因此，当热力学稳定的油包水微乳液与静电纺丝过程中固有的溶剂快速蒸发相结合时，液滴转变成嵌入聚合物纳米纤维中的有机纳米颗粒。除了具有工艺简单的优点外，该方法还表现出非常高的纳米颗粒负载百分比和理想的活性材料性能。具体而言，纳米纤维的直径在 60-185nm 范围内，对羟基苯甲酸丙酯以 30-120nm 的纳米晶体形式存在于纳米纤维内。这些尺寸表明纳米纤维-纳米晶体复合材料可以用作水不溶性材料的输送系统。
