Institute of Chemistry, The Hebrew University of Jerusalem, Jerusalem 91904, Israel.
J Colloid Interface Sci. 2010 Feb 15;342(2):283-92. doi: 10.1016/j.jcis.2009.10.024. Epub 2009 Oct 17.
A method for preparation of nanoparticles of poorly water-soluble organic materials is presented. By this method, an oil-in-water microemulsion containing a volatile solvent with dissolved model material, propylparaben, undergoes solvent evaporation and conversion into nanoparticles by spray drying. The resulting powder can be easily dispersed in water to give a clear, stable dispersion of nanoparticles with a high loading of propylparaben. By filtration of this dispersion it was found that more than 95wt.% of the dispersed propylparaben is in particles of less than 450nm. X-ray diffraction revealed that propylparaben is present as nanocrystals of 40-70nm. After dispersion of the powder in water, formation of large crystals rapidly occurs. Addition of polyvinylpyrrolidone (PVP) prevented crystal growth during dispersion of the powder in water. The inhibition of propylparaben crystal growth by PVP was studied by molecular dynamic simulations that addressed the binding of PVP to the propylparaben crystal. A comparison was made between PVP and polyvinylalcohol, which did not display crystal inhibition properties.
一种制备疏水性有机材料纳米颗粒的方法。通过该方法，含有挥发性溶剂和溶解的模型材料对羟基苯甲酸丙酯的油包水微乳液经历溶剂蒸发，并通过喷雾干燥转化为纳米颗粒。所得粉末可以很容易地分散在水中，得到高载药量对羟基苯甲酸丙酯的澄清、稳定的纳米颗粒分散体。通过这种分散体的过滤发现，分散的对羟基苯甲酸丙酯中超过 95wt%的物质处于小于 450nm 的颗粒中。X 射线衍射表明，对羟基苯甲酸丙酯以 40-70nm 的纳米晶体形式存在。粉末在水中分散后，大晶体迅速形成。添加聚乙烯吡咯烷酮 (PVP) 可防止粉末在水中分散时晶体生长。通过分子动力学模拟研究了 PVP 对丙泊酚晶体生长的抑制作用，该模拟研究了 PVP 与丙泊酚晶体的结合。比较了 PVP 和聚乙烯醇，后者不显示出抑制晶体生长的性质。
