School of Clinical Science, University of Bristol, UK.
Acta Paediatr. 2012 Jul;101(7):743-8. doi: 10.1111/j.1651-2227.2012.02686.x. Epub 2012 Apr 28.
To correlate volumetric magnetic resonance imaging at term with neurodevelopmental outcome at 2 years in infants with posthaemorrhagic ventricular dilatation. Preterm infants with posthaemorrhagic ventricular dilatation have high risk of disabilities, but the range is wide and predicting severity of motor and mental disability is difficult.
Twenty-five preterm infants with posthaemorrhagic ventricular dilatation had cerebral magnetic resonance imaging at term age. Total and regional brain volumes were calculated using a manual segmentation technique. Bayley Scales of Infant Development II were assessed at 2 years post-term. Developmental Quotients (DQ) were calculated from Developmental Age Equivalent scores.
Total cerebral volume, excluding ventricles, correlated positively with Motor (r = 0.7, p < 0.0001) and Mental DQ (r = 0.4, p = 0.02). Only three of 16 infants with cerebral volume <336 cm(3) were ambulant at 2 years. Cerebellar volumes correlated strongly with Motor DQ (r = 0.6, p = 0.002) but only with Mental DQ after adjustment. Thalamic volumes correlated strongly with Motor DQ (r = 0.7, p = 0.0002).
Brain growth is significantly impaired in posthaemorrhagic ventricular dilatation. Volumetric measurements at term of total cerebral and cerebellar volume may have a role in predicting severity of disability.
通过足月时的磁共振体积成像（MRI）与伴有出血后脑室扩张的早产儿 2 岁时的神经发育结局相关联。伴有出血后脑室扩张的早产儿有残疾的高风险，但范围很广，预测运动和智力残疾的严重程度很困难。
25 例伴有出血后脑室扩张的早产儿在足月时进行了脑 MRI。使用手动分割技术计算总脑体积和区域脑体积。在纠正年龄 2 岁时采用贝利婴幼儿发育量表第二版（Bayley Scales of Infant Development II）进行评估。从发育年龄相当分数计算发育商（DQ）。
总脑体积（不包括脑室）与运动（r = 0.7，p < 0.0001）和智力 DQ（r = 0.4，p = 0.02）呈正相关。只有 16 例脑容量 <336cm3 的婴儿中有 3 例在 2 岁时能行走。小脑体积与运动 DQ 呈强相关（r = 0.6，p = 0.002），但经调整后仅与智力 DQ 相关。丘脑体积与运动 DQ 呈强相关（r = 0.7，p = 0.0002）。
出血后脑室扩张患儿的脑生长明显受损。足月时总脑和小脑体积的体积测量可能有助于预测残疾的严重程度。
