Banik Mandira, Ramirez Bianca, Reddy Ashwini, Bandyopadhyay Debasish, Banik Bimal K
Department of Chemistry, The University of Texas-Pan American, 1201 West University Drive, Edinburg, TX 78539, USA.
Org Med Chem Lett. 2012 Mar 27;2(1):11. doi: 10.1186/2191-2858-2-11.
The classical Paal-Knorr reaction is one of the simplest and most economical methods for the synthesis of biologically important and pharmacologically useful pyrrole derivatives.
Polystyrenesulfonate-catalyzed simple synthesis of substituted pyrroles following Paal-Knorr reaction has been accomplished with an excellent yield in aqueous solution. This method also produces pyrroles with multicyclic polyaromatic amines.
The present procedure for the synthesis of N-polyaromatic substituted pyrroles will find application in the synthesis of potent biologically active molecules.
经典的帕尔-克诺尔反应是合成具有生物学重要性和药理学用途的吡咯衍生物的最简单、最经济的方法之一。
在水溶液中，聚苯乙烯磺酸盐催化的、遵循帕尔-克诺尔反应的取代吡咯的简单合成已以优异的产率完成。该方法还能生成带有多环多芳基胺的吡咯。
目前合成N-多芳基取代吡咯的方法将在强效生物活性分子的合成中得到应用。
