• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

多环芳香化合物作为抗癌剂：一些屈衍生物的合成与生物学评价

Polycyclic aromatic compounds as anticancer agents: synthesis and biological evaluation of some chrysene derivatives.

作者信息

Becker F F, Banik B K

机构信息

University of Texas, M.D. Anderson Cancer Center, Department of Molecular Pathology, Houston 77030, USA.

出版信息

Bioorg Med Chem Lett. 1998 Oct 20;8(20):2877-80. doi: 10.1016/s0960-894x(98)00520-4.

DOI:10.1016/s0960-894x(98)00520-4
PMID:9873640
Abstract

Synthesis and biological evaluation of new chrysene derivatives aimed at the development of anticancer agents were carried out.

摘要

开展了旨在开发抗癌药物的新型屈衍生物的合成及生物学评价。

相似文献

1
Polycyclic aromatic compounds as anticancer agents: synthesis and biological evaluation of some chrysene derivatives.多环芳香化合物作为抗癌剂：一些屈衍生物的合成与生物学评价
Bioorg Med Chem Lett. 1998 Oct 20;8(20):2877-80. doi: 10.1016/s0960-894x(98)00520-4.
2
Novel 6,12-disubstituted chrysene as potent anticancer agent: synthesis, in vitro and in vivo study.新型 6,12-二取代苝作为有效的抗癌剂：合成、体外和体内研究。
Eur J Med Chem. 2010 Oct;45(10):4687-91. doi: 10.1016/j.ejmech.2010.07.033. Epub 2010 Jul 24.
3
Polycyclic aromatic compounds as anticancer agents: structure-activity relationships of chrysene and pyrene derivatives.多环芳香化合物作为抗癌剂：屈和芘衍生物的构效关系
Bioorg Med Chem. 2001 Mar;9(3):593-605. doi: 10.1016/s0968-0896(00)00297-2.
4
Synthesis, topoisomerase I inhibition and antitumor cytotoxicity of 2,2':6',2"-, 2,2':6',3"- and 2,2':6',4"-terpyridine derivatives.
Bioorg Med Chem Lett. 2001 Oct 8;11(19):2659-62. doi: 10.1016/s0960-894x(01)00531-5.
5
Design, synthesis and pharmacological evaluation of new anticancer fused pentacycles.
J Enzyme Inhib Med Chem. 2003 Apr;18(2):95-9. doi: 10.1080/1475636031000093525.
6
Antitumor agents. Synthesis and biological evaluation of new compounds related to podophyllotoxin, containing the 2,3-dihydro-1,4-benzodioxin system.抗肿瘤剂。含2,3-二氢-1,4-苯并二恶英体系的鬼臼毒素相关新化合物的合成与生物学评价。
Eur J Med Chem. 2001 Apr;36(4):389-93. doi: 10.1016/s0223-5234(01)01231-4.
7
Design, synthesis and biological evaluation of novel pyrenyl derivatives as anticancer agents.新型芘基衍生物作为抗癌剂的设计、合成及生物学评价
Eur J Med Chem. 2015 Jan 7;89:851-62. doi: 10.1016/j.ejmech.2014.09.072. Epub 2014 Sep 28.
8
Diaza- and triazachrysenes: potent topoisomerase-targeting agents with exceptional antitumor activity against the human tumor xenograft, MDA-MB-435.二氮杂和三氮杂并四苯：靶向拓扑异构酶的强效药物，对人肿瘤异种移植模型MDA-MB-435具有卓越的抗肿瘤活性。
Bioorg Med Chem Lett. 2002 Nov 18;12(22):3333-6. doi: 10.1016/s0960-894x(02)00737-0.
9
Synthesis and antitumor activity of 4-hydroxycoumarin derivatives.4-羟基香豆素衍生物的合成及其抗肿瘤活性
Bioorg Med Chem Lett. 2004 Nov 15;14(22):5527-31. doi: 10.1016/j.bmcl.2004.09.009.
10
Polycyclic aromatic compounds as anticancer agents: synthesis and biological evaluation of dibenzofluorene derivatives.多环芳香化合物作为抗癌剂：二苯并芴衍生物的合成与生物学评价
Bioorg Med Chem. 2000 Dec;8(12):2693-9. doi: 10.1016/s0968-0896(00)00213-3.

引用本文的文献

1
Synthesis of some new pyrimidine-based pyrene/benzochromene hybrids as EGFR kinase inhibitors in HCT-116 cancer cells through apoptosis.通过凋亡作用合成一些新型嘧啶基芘/苯并色烯杂化物作为HCT-116癌细胞中的表皮生长因子受体（EGFR）激酶抑制剂。
RSC Adv. 2025 Aug 28;15(37):30683-30696. doi: 10.1039/d5ra03611a. eCollection 2025 Aug 22.
2
Synthesis of Novel Nitro-Halogenated Aryl-Himachalene Sesquiterpenes from Atlas Cedar Oil Components: Characterization, DFT Studies, and Molecular Docking Analysis against Various Isolated Smooth Muscles.由雪松油成分合成新型硝基卤代芳基-喜马拉雅烯倍半萜：表征、密度泛函理论研究及对各种离体平滑肌的分子对接分析
Molecules. 2024 Jun 18;29(12):2894. doi: 10.3390/molecules29122894.
3
Polycyclic aromatic compounds as anticancer agents: synthesis and biological evaluation of methoxy dibenzofluorene derivatives.
多环芳烃类化合物作为抗癌药物：甲氧基二苯并芴衍生物的合成与生物评价。
Front Chem. 2014 Aug 1;2:55. doi: 10.3389/fchem.2014.00055. eCollection 2014.
4
A personal perspective on medicinal and pharmaceutical chemistry.关于药物化学与制药化学的个人观点。
Front Chem. 2014 Feb 27;2:8. doi: 10.3389/fchem.2014.00008. eCollection 2014.
5
An expeditious iodine-catalyzed synthesis of 3-pyrrole-substituted 2-azetidinones.一种快速的碘催化合成 3-吡咯取代的 2-氮杂环丁酮的方法。
Molecules. 2012 Sep 28;17(10):11570-84. doi: 10.3390/molecules171011570.
6
Synthesis and biological evaluation of novel dibenzofluorene derivatives as anticancer agents.新型二苯并芴衍生物作为抗癌剂的合成及生物学评价
Oncol Lett. 2010 Mar;1(2):309-311. doi: 10.3892/ol_00000055. Epub 2010 Mar 1.
7
Polycyclic aromatic compounds as anticancer agents: Evaluation of synthesis and in vitro cytotoxicity.多环芳香族化合物作为抗癌剂：合成与体外细胞毒性评估。
Oncol Lett. 2012 Jan;3(1):45-49. doi: 10.3892/ol.2011.436. Epub 2011 Oct 4.
8
Microwave-assisted polystyrene sulfonate-catalyzed synthesis of novel pyrroles.微波辅助聚苯乙烯磺酸盐催化合成新型吡咯。
Org Med Chem Lett. 2012 Jun 22;2(1):24. doi: 10.1186/2191-2858-2-24.
9
Polystyrenesulfonate-catalyzed synthesis of novel pyrroles through Paal-Knorr reaction.聚苯乙烯磺酸盐催化通过帕尔-克诺尔反应合成新型吡咯。
Org Med Chem Lett. 2012 Mar 27;2(1):11. doi: 10.1186/2191-2858-2-11.
10
A microwave-assisted bismuth nitrate-catalyzed unique route toward 1,4-dihydropyridines.微波辅助硝酸铋催化的独特路线合成 1,4-二氢吡啶。
Molecules. 2012 Mar 5;17(3):2643-62. doi: 10.3390/molecules17032643.