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缺氧诱导因子-2a 与乳腺浸润性导管癌中 ABCG2 表达、组织学分级和 Ki67 表达相关。

Hypoxia-inducible factor-2a is associated with ABCG2 expression, histology-grade and Ki67 expression in breast invasive ductal carcinoma.

机构信息

Department of Pathology, School of Medicine, Shandong University, Jinan, Shandong, People's Republic of China.

出版信息

Diagn Pathol. 2012 Mar 27;7:32. doi: 10.1186/1746-1596-7-32.

DOI:10.1186/1746-1596-7-32
PMID:22452996
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3337233/
Abstract

BACKGROUND

Breast cancer is the most common cancer and the leading cause of cancer mortality in women worldwide. Hypoxia is an important factor involved in the progression of solid tumors and has been associated with various indicators of tumor metabolism, angiogenesis and metastasis. But little is known about the contribution of Hypoxia-Inducible Factor-2a (HIF-2a) to the drug resistance and the clinicopathological characteristics in breast cancer.

METHODS

Immunohistochemistry was employed on the tissue microarray paraffin sections of surgically removed samples from 196 invasive breast cancer patients with clinicopathological data. The correlations between the expression of HIF-2a and ABCG2 as well as other patients' clinicopathological data were investigated.

RESULTS

The results showed that HIF-2a was expressed in different intensities and distributions in the tumor cells of the breast invasive ductal carcinoma. A positive staining for HIF-2a was defined as a brown staining observed mainly in the nucleus. A statistically significant correlation was demonstrated between HIF-2a expression and ABCG2 expression (p = 0.001), histology-grade (p = 0.029), and Ki67 (p = 0. 043) respectively.

CONCLUSION

HIF-2a was correlated with ABCG2 expression, histology-grade and Ki67 expression in breast invasive ductal carcinoma. HIF-2a could regulate ABCG2 in breast cancer cells, and could be a novel potential bio-marker to predict chemotherapy effectiveness. The hypoxia/HIF-2a/ABCG2 pathway could be a new mechanism of breast cancer multidrug-resistance.

VIRTUAL SLIDES

http://www.diagnosticpathology.diagnomx.eu/vs/2965948166714795.

摘要

背景

乳腺癌是全球最常见的癌症，也是女性癌症死亡的主要原因。缺氧是实体瘤进展的一个重要因素，与肿瘤代谢、血管生成和转移的各种指标有关。但对于缺氧诱导因子-2a（HIF-2a）对乳腺癌耐药性和临床病理特征的贡献知之甚少。

方法

采用免疫组织化学方法对 196 例手术切除的浸润性乳腺癌患者组织微阵列石蜡切片进行检测，并结合临床病理资料进行分析。探讨 HIF-2a 与 ABCG2 表达及其他患者临床病理资料的相关性。

结果

结果显示，HIF-2a 在乳腺浸润性导管癌的肿瘤细胞中呈不同强度和分布的表达。HIF-2a 阳性染色定义为主要在细胞核中观察到的棕色染色。HIF-2a 表达与 ABCG2 表达（p = 0.001）、组织学分级（p = 0.029）和 Ki67（p = 0.043）呈显著相关。

结论

HIF-2a 与乳腺浸润性导管癌中的 ABCG2 表达、组织学分级和 Ki67 表达相关。HIF-2a 可调节乳腺癌细胞中的 ABCG2，可能成为预测化疗效果的新的潜在生物标志物。缺氧/HIF-2a/ABCG2 通路可能是乳腺癌多药耐药的新机制。

幻灯片

http://www.diagnosticpathology.diagnomx.eu/vs/2965948166714795.

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/088d/3337233/d037dbd9b04d/1746-1596-7-32-5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/088d/3337233/d17261ea9212/1746-1596-7-32-1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/088d/3337233/4300e7ab22cb/1746-1596-7-32-2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/088d/3337233/b9aeab3c2759/1746-1596-7-32-3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/088d/3337233/ca2acd19cd1d/1746-1596-7-32-4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/088d/3337233/d037dbd9b04d/1746-1596-7-32-5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/088d/3337233/d17261ea9212/1746-1596-7-32-1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/088d/3337233/4300e7ab22cb/1746-1596-7-32-2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/088d/3337233/b9aeab3c2759/1746-1596-7-32-3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/088d/3337233/ca2acd19cd1d/1746-1596-7-32-4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/088d/3337233/d037dbd9b04d/1746-1596-7-32-5.jpg

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