miR-146A 在造血、免疫功能和癌症控制中的新兴作用。
The emerging role of MIR-146A in the control of hematopoiesis, immune function and cancer.
机构信息
Department of Hematology, Oncology and Molecular Medicine, Istituto Superiore di Sanità, Viale Regina Elena 299, 00161 Rome, Italy.
出版信息
J Hematol Oncol. 2012 Mar 27;5:13. doi: 10.1186/1756-8722-5-13.
Abstract
MicroRNA (miRs) represent a class of small non-coding regulatory RNAs playing a major role in the control of gene expression by repressing protein synthesis at the post-transcriptional level. Studies carried out during the last years have shown that some miRNAs plays a key role in the control of normal and malignant hgematopoiesis. In this review we focus on recent progress in analyzing the functional role of miR-146a in the control of normal and malignant hematopoiesis. On the other hand, this miRNA has shown to impact in the control of innate immune responses. Finally, many recent studies indicate a deregulation of miR-146 in many solid tumors and gene knockout studies indicate a role for this miRNA as a tumor suppressor.
摘要
MicroRNA (miRs) 是一类小的非编码调控 RNA，通过在转录后水平抑制蛋白质合成，在基因表达的调控中发挥主要作用。近年来的研究表明，一些 miRNA 在正常和恶性造血的调控中起着关键作用。在这篇综述中，我们重点分析了 miR-146a 在正常和恶性造血调控中的功能作用。另一方面，这种 miRNA 已被证明会影响固有免疫反应的控制。最后，许多最近的研究表明，miR-146 在许多实体瘤中失调，基因敲除研究表明，这种 miRNA 作为肿瘤抑制因子发挥作用。
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Blood Cancer J. 2011 Jun;1(6):e26. doi: 10.1038/bcj.2011.24. Epub 2011 Jun 24.
2
MicroRNA alterations of pancreatic intraepithelial neoplasias.胰腺上皮内瘤变的微小 RNA 改变。
Clin Cancer Res. 2012 Feb 15;18(4):981-92. doi: 10.1158/1078-0432.CCR-11-2347. Epub 2011 Nov 23.
3
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Cancer Res. 2012 Jan 1;72(1):335-45. doi: 10.1158/0008-5472.CAN-11-2182. Epub 2011 Nov 22.
4
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Mol Biol Rep. 2012 Apr;39(4):4655-61. doi: 10.1007/s11033-011-1257-5. Epub 2011 Sep 23.
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