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Exploring the therapeutic potential of MSC-derived secretomes in neonatal care: focus on BPD and NEC.

作者信息

Azad Tasnim, Wu Feifeng, Mao Jueyi, Zhu Junquan, Wang Yang, Zhou Xin, Hong Kimsor, Xie Haotian, Qiu Xinying, Li Binbin, Zhang Liang, Tian Jidong, Wen Chuan

机构信息

Department of Pediatrics, The Second Xiangya Hospital of Central South University, Changsha, China.

The Affiliated Children's Hospital of Xiangya School of Medicine, Central South University, Changsha, China.

出版信息

Stem Cell Res Ther. 2025 Aug 29;16(1):476. doi: 10.1186/s13287-025-04616-8.

DOI:10.1186/s13287-025-04616-8
PMID:40883791
Abstract
摘要

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本文引用的文献

1
Secretome and extracellular vesicle signatures in bone marrow-derived mesenchymal stromal cells after expansion in standard and next-generation media.在标准培养基和新一代培养基中扩增后骨髓间充质基质细胞的分泌组和细胞外囊泡特征
Extracell Vesicles Circ Nucl Acids. 2025 Apr 29;6(2):195-215. doi: 10.20517/evcna.2024.99. eCollection 2025.
2
M2 macrophages activate the IL-10/JAK2/STAT3 pathway to induce pathological microangiogenesis in the nucleus pulposus exacerbating intervertebral disc degeneration.M2巨噬细胞激活IL-10/JAK2/STAT3通路，诱导髓核病理性微血管生成，加剧椎间盘退变。
J Orthop Surg Res. 2025 May 28;20(1):532. doi: 10.1186/s13018-025-05962-2.
3
Delivery of bone marrow mesenchymal stem cell-derived exosomes into fibroblasts attenuates intestinal fibrosis by weakening its transdifferentiation via the CCN2-TGF-β axis.
将骨髓间充质干细胞衍生的外泌体递送至成纤维细胞可通过CCN2-转化生长因子-β轴减弱其转分化来减轻肠道纤维化。
Sci Rep. 2025 May 23;15(1):18048. doi: 10.1038/s41598-025-02971-3.
4
Continuous collection of human mesenchymal-stromal-cell-derived extracellular vesicles from a stirred tank reactor operated under xenogeneic-free conditions for therapeutic applications.在无异种条件下运行的搅拌罐反应器中连续收集人源间充质基质细胞衍生的细胞外囊泡用于治疗应用。
Stem Cell Res Ther. 2025 Apr 24;16(1):210. doi: 10.1186/s13287-025-04341-2.
5
Fine-tuning licensing strategies to boost MSC-based immunomodulatory secretome.微调许可策略以增强基于间充质干细胞的免疫调节分泌组。
Stem Cell Res Ther. 2025 Apr 17;16(1):183. doi: 10.1186/s13287-025-04315-4.
6
The influence of cell source on the senescence of human mesenchymal stem/stromal cells.细胞来源对人骨髓间充质干细胞衰老的影响。
Hum Cell. 2025 Apr 12;38(3):87. doi: 10.1007/s13577-025-01213-y.
7
Pyroptosis-preconditioned mesenchymal stromal cell-derived extracellular vesicles as advanced nanomedicines for treating inflammatory diseases.焦亡预处理的间充质基质细胞衍生的细胞外囊泡作为治疗炎症性疾病的先进纳米药物
Biomater Sci. 2025 May 13;13(10):2690-2703. doi: 10.1039/d4bm01505c.
8
WNT5a export onto extracellular vesicles studied at single-molecule and single-vesicle resolution.在单分子和单囊泡分辨率下研究WNT5a向细胞外囊泡的输出。
FEBS J. 2025 Apr 1. doi: 10.1111/febs.70074.
9
Mesenchymal stem cell-derived exosomes as a plausible immunomodulatory therapeutic tool for inflammatory diseases.间充质干细胞衍生的外泌体作为一种用于炎症性疾病的合理免疫调节治疗工具。
Front Cell Dev Biol. 2025 Mar 10;13:1563427. doi: 10.3389/fcell.2025.1563427. eCollection 2025.
10
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Stem Cell Res Ther. 2025 Mar 24;16(1):145. doi: 10.1186/s13287-025-04266-w.