Chao Linda L, Lenoci Maryann, Neylan Thomas C
Department of Radiology and Biomedical Imaging, University of California, USA.
Neuroreport. 2012 May 9;23(7):412-9. doi: 10.1097/WNR.0b013e328352025e.
Although there is evidence for strong connectivity between the amygdala and the visual cortex and some evidence for reduced occipital lobe gray matter volume in patients with post-traumatic stress disorder (PTSD), few studies have directly examined the effects of PTSD on occipital function. The current study used functional and structural MRI to examine occipital cortex function and structure in male combat veterans with and without PTSD. Left occipital gray matter volume was reduced in PTSD patients relative to the controls and correlated negatively with the severity of PTSD symptoms. Functional activity in the lateral occipital complex to aversive and nonaversive pictures presented in novel and repeated presentations was not altered by PTSD. These findings suggest that PTSD adversely affects occipital lobe volume but not the reactivity of the lateral occipital complex to generally aversive, trauma nonspecific stimuli.
尽管有证据表明杏仁核与视觉皮层之间存在紧密连接，并且有一些证据显示创伤后应激障碍（PTSD）患者枕叶灰质体积减少，但很少有研究直接考察PTSD对枕叶功能的影响。本研究采用功能和结构磁共振成像来检查患有和未患有PTSD的男性退伍军人的枕叶皮层功能和结构。与对照组相比，PTSD患者左侧枕叶灰质体积减少，且与PTSD症状的严重程度呈负相关。PTSD并未改变枕外侧复合体对新呈现和重复呈现的厌恶及非厌恶图片的功能活动。这些发现表明，PTSD会对枕叶体积产生不利影响，但不会影响枕外侧复合体对一般厌恶、创伤非特异性刺激的反应性。
