Skene D J, Vivien-Roels B, Sparks D L, Hunsaker J C, Pévet P, Ravid D, Swaab D F
CNRS-URA 1332, Neurobiologie des fonctions rythmiques et saisonnières, Université Louis Pasteur, Strasbourg, France.
Brain Res. 1990 Sep 24;528(1):170-4. doi: 10.1016/0006-8993(90)90214-v.
Melatonin and 5-methoxytryptophol (ML) were measured in human pineals (38 controls, 16 subjects with Alzheimer's disease). Time of death had a major influence on the indole concentrations with significantly higher melatonin levels occurring at night (22.00-10.00 h) and significantly higher ML levels occurring during the day (10.00-22.00 h). This daily variation disappeared in both the older subjects (55-92 years) and in the Alzheimer patients (55-89 years).
在人体松果体中测量了褪黑素和5-甲氧基色醇（ML）（38名对照者，16名阿尔茨海默病患者）。死亡时间对吲哚浓度有重大影响，夜间（22:00 - 10:00）褪黑素水平显著更高，白天（10:00 - 22:00）ML水平显著更高。这种每日变化在老年受试者（55 - 92岁）和阿尔茨海默病患者（55 - 89岁）中均消失。
