Rheumatology and Internal Medicine Department, Central Clinical Hospital, Ministry of Internal Affairs and Administration, ul. Wołoska 137, 02-507 Warsaw, Poland.
Rheumatol Int. 2013 Feb;33(2):429-34. doi: 10.1007/s00296-012-2421-5. Epub 2012 Mar 28.
There are studies about health-related quality of life (HRQoL) in patients with rheumatoid arthritis (RA), but few studies prospectively assessed HRQoL. The main purpose of this study was to analyze HRQoL in patients hospitalized due to RA exacerbation and observed over a planned 2-year follow-up in an outpatient setting. The study involved 42 women and 9 men, at mean age of 62.5 years (SD ± 12.6). The mean duration of the study was 22-23 months. The HRQoL analysis was performed using the SF-36 survey. At the beginning of the study, basic data on age, sex, selected biochemical (ESR, CRP, GFR, hemoglobin, plasma albumin, plasma protein), and clinical parameters (the duration of RA, VAS, DAS28, BMI, the presence of cardiovascular disease, diabetes, osteoporosis, osteoporotic fractures, osteoarthritis, neoplasm) were collected. Questionnaires were completed at the beginning and end of the study. Statistically significant reductions in HRQoL scores were observed in social functioning (SF; 0.42 vs 0.32, P < 0.05), whereas role-emotional health (RE; 0.48 vs 0.59, P < 0.05) and mental health (MH; 0.47 vs 0.54, P < 0.05) scores were increased. A decrease in the SF was positively correlated with the lack of osteoporosis at baseline (r = 0.35, P > 0.02). An increase in the MH was inversely correlated with BMI (r = -0.31, P < 0.05), and the level of hemoglobin (r = -0.32, P < 0.028) and positively correlated with the presence of osteoarthritis at baseline (r = 0.29, P < 0.05). In RA patients, dimensions of HRQoL as SF, RE, and MH could change within 2 years and these changes could be related to comorbidities. Although preliminary findings are promising, further studies are needed.
有关于类风湿关节炎（RA）患者健康相关生活质量（HRQoL）的研究，但很少有前瞻性评估 HRQoL 的研究。本研究的主要目的是分析因 RA 恶化而住院并在门诊环境中进行为期 2 年计划随访中患者的 HRQoL。该研究纳入了 42 名女性和 9 名男性，平均年龄为 62.5 岁（标准差 ± 12.6）。研究的平均持续时间为 22-23 个月。HRQoL 分析使用 SF-36 调查进行。在研究开始时，收集了年龄、性别、选定的生化指标（ESR、CRP、GFR、血红蛋白、血浆白蛋白、血浆蛋白）和临床参数（RA 持续时间、VAS、DAS28、BMI、心血管疾病、糖尿病、骨质疏松症、骨质疏松性骨折、骨关节炎、肿瘤）的基本数据。在研究开始和结束时完成了问卷。观察到社会功能（SF；0.42 比 0.32，P < 0.05）和角色情感健康（RE；0.48 比 0.59，P < 0.05）和心理健康（MH；0.47 比 0.54，P < 0.05）评分显著降低。SF 的降低与基线时无骨质疏松症呈正相关（r = 0.35，P > 0.02）。MH 的增加与 BMI 呈负相关（r = -0.31，P < 0.05），与血红蛋白水平呈负相关（r = -0.32，P < 0.028），与基线时存在骨关节炎呈正相关（r = 0.29，P < 0.05）。在 RA 患者中，SF、RE 和 MH 等 HRQoL 维度可能在 2 年内发生变化，这些变化可能与合并症有关。尽管初步发现很有希望，但仍需要进一步研究。
