Müller-Wieland D, Knebel B, Haas J, Kotzka J
Herz-, Gefäß- und Diabeteszentrum u. Abteilung für Allgemeine Innere Medizin, Asklepios Klinik St. Georg, Asklepios Campus Hamburg, Medizinische Fakultät der Semmelweis-Universität, Lohmühlenstr. 5, 20099, Hamburg, Deutschland.
Herz. 2012 May;37(3):273-8. doi: 10.1007/s00059-012-3608-y.
Insulin resistance and visceral fat distribution usually play a major role in the development of clinical aspects of the metabolic syndrome, such as dyslipidemia, diabetes and atherosclerosis. In this review, the focus will be on some novel relationships with a fatty liver, for which susceptibility appears to be mediated by the activity of transcription factors, such as sterol regulatory element-binding protein 1 (SREBP-1). In addition to this molecular aspect therapeutic life-style modifications, such as weight reduction which are associated with increased insulin sensitivity and a decrease of fat in the liver will be discussed.
胰岛素抵抗和内脏脂肪分布通常在代谢综合征临床症状的发展中起主要作用，如血脂异常、糖尿病和动脉粥样硬化。在本综述中，重点将放在与脂肪肝的一些新关系上，脂肪肝的易感性似乎由转录因子的活性介导，如固醇调节元件结合蛋白1（SREBP-1）。除了这一分子层面，还将讨论治疗性生活方式的改变，如减轻体重，这与胰岛素敏感性增加和肝脏脂肪减少有关。
