Wadley Alex J, Veldhuijzen van Zanten Jet J C S, Aldred Sarah
School of Sport and Exercise Sciences, The University of Birmingham, Edgbaston, Birmingham, B15 2TT, UK.
Age (Dordr). 2013 Jun;35(3):705-18. doi: 10.1007/s11357-012-9402-1. Epub 2012 Mar 28.
Oxidative stress and inflammation are increased with advancing age. Evidence suggests that oxidative stress and inflammation both lead to impaired vascular function. There is also evidence to suggest that inflammation may cause an increase in radical production leading to enhanced oxidative stress. In addition, oxidative stress may cause an increase in inflammation; however, the interactions between these factors are not fully understood. In this review, we propose the vascular health triad, which draws associations and interactions between oxidative stress and inflammation seen in ageing, and the consequences for vascular function. We review evidence suggesting that exercise may ameliorate the age-related decline in vascular function, through reductions in both oxidative stress and inflammation.
随着年龄的增长，氧化应激和炎症反应会增加。有证据表明，氧化应激和炎症都会导致血管功能受损。也有证据表明，炎症可能会导致自由基产生增加，从而增强氧化应激。此外，氧化应激可能会导致炎症增加；然而，这些因素之间的相互作用尚未完全了解。在本综述中，我们提出了血管健康三联征，它描绘了衰老过程中氧化应激和炎症之间的关联和相互作用，以及对血管功能的影响。我们回顾了相关证据，这些证据表明运动可能通过减少氧化应激和炎症来改善与年龄相关的血管功能衰退。
