Laboratory of Metabolic Medicine, Singapore Bioimaging Consortium, Agency for Science, Technology and Research, Singapore.
Adv Exp Med Biol. 2012;740:731-57. doi: 10.1007/978-94-007-2888-2_32.
Neurotransmitters, neuropeptides and hormones are released through regulated exocytosis of synaptic vesicles and large dense core vesicles. This complex and highly regulated process is orchestrated by SNAREs and their associated proteins. The triggering signal for regulated exocytosis is usually an increase in intracellular calcium levels. Besides the triggering role, calcium signaling modulates the precise amount and kinetics of vesicle release. Thus, it is a central question to understand the molecular machineries responsible for calcium sensing in exocytosis. Here we provide an overview of our current understanding of calcium sensing in neurotransmitter release and hormone secretion.
神经递质、神经肽和激素通过突触小泡和大致密核心囊泡的受调控胞吐作用释放。这个复杂且高度调控的过程由 SNARE 及其相关蛋白协调完成。受调控胞吐的触发信号通常是细胞内钙离子浓度的增加。除了触发作用外，钙信号还调节囊泡释放的精确数量和动力学。因此，了解负责胞吐作用中钙感应的分子机制是一个核心问题。本文概述了我们目前对神经递质释放和激素分泌中钙感应的理解。
