Inserm UMRS 956/ Université Pierre et Marie Curie Paris6, 91 boulevard de l'hôpital, 75013 Paris, France.
Adv Exp Med Biol. 2012;740:795-810. doi: 10.1007/978-94-007-2888-2_35.
Cyclic variations in calcium (Ca(2+)) concentrations, through a process called excitation-contraction coupling, allow regulation of vascular smooth muscle cells contractility and thus modulation of vascular tone and blood pressure. As a second messenger, Ca(2+) also activates signaling cascades leading to transcription factors activation in a process called excitation-transcription coupling. Furthermore, recent evidences indicate an interaction between post-transcriptional regulation by microRNAs (miRNAs) and Ca(2+) signaling. All these actors, which are frequently altered in vascular diseases, will be reviewed here.
钙（Ca(2+)）浓度的循环变化通过一种称为兴奋-收缩偶联的过程来调节血管平滑肌细胞的收缩性，从而调节血管张力和血压。作为第二信使，Ca(2+)还激活信号级联反应，导致称为兴奋-转录偶联的转录因子激活。此外，最近的证据表明，miRNAs（microRNAs）的转录后调控与 Ca(2+)信号之间存在相互作用。所有这些在血管疾病中经常发生改变的因子都将在这里进行综述。
