肾脏管状细胞中的钙信号传导。

Calcium signaling in renal tubular cells.

机构信息

Nephrology Research Laboratory, IRB Lleida, University Hospital Arnau de Vilanova, Rovira Roure 80, Planta 1, 25198 Lleida, Spain.

出版信息

Adv Exp Med Biol. 2012;740:933-44. doi: 10.1007/978-94-007-2888-2_42.

DOI:10.1007/978-94-007-2888-2_42

PMID:22453977

Abstract

The kidney handles calcium by filtration and reabsorption. About 60% of the plasma calcium is filterable, and 99% is reabsorbed in the tubule. In the proximal tubule, the reabsorption is passive and paracellular, but in the distal tubule is active and transcellular. Thus, renal tubular cells are exposed to very high concentrations of calcium in both, the extracellular and the intracellular compartments. Extracellular calcium signaling is transmitted by the calcium sensing receptor, located both in the luminal and basolateral sides of tubular cells. This receptor is able to control levels of extracellular calcium and acts in consequence to maintain calcium homeostasis. Furthermore, renal tubular cells possess several calcium channels that regulate some of the cell functions. Among those, voltage gated calcium channels, transient receptor potential channels and N-methyl-D-aspartate receptor channels have been reported to control several functions. Those functions include survival, apoptosis, differentiation, epithelial-mesenchymal transition, and active vitamin D and renin synthesis.

摘要

肾脏通过过滤和重吸收来处理钙。约 60%的血浆钙可被过滤，99%在肾小管中被重吸收。在近端小管中，重吸收是被动的和细胞旁的，但在远端小管中是主动的和细胞内的。因此，肾小管细胞在细胞外和细胞内间隙中都暴露于非常高的钙浓度下。细胞外钙信号通过钙敏感受体传递，该受体位于肾小管细胞的腔侧和基底外侧。该受体能够控制细胞外钙水平，并相应地作用以维持钙稳态。此外，肾小管细胞还具有几种钙通道，可调节某些细胞功能。其中，电压门控钙通道、瞬时受体电位通道和 N-甲基-D-天冬氨酸受体通道已被报道可控制多种功能。这些功能包括生存、凋亡、分化、上皮-间充质转化以及活性维生素 D 和肾素的合成。