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[老年人贫血与缺铁。患病率、诊断及新的治疗选择]

[Anemia and iron deficiency in the elderly. Prevalence, diagnostics and new therapeutic options].

作者信息

Röhrig G, Doehner W, Schaefer R M, Schulz R J

机构信息

Klinik für Geriatrie, St.-Marien-Hospital Köln, Kunibertskloster 11-13, 50668, Köln, Deutschland.

出版信息

Z Gerontol Geriatr. 2012 Apr;45(3):191-6. doi: 10.1007/s00391-012-0320-8.

DOI:10.1007/s00391-012-0320-8
PMID:22454095
Abstract

The prevalence of anemia in geriatric patients is high. With some variation in different patient cohorts, prevalence of anemia can reach 40%. Anemia is not an age-related disease on its own, but is a symptom with multifactorial genesis and high risk potential. It directly influences mortality, morbidity, and the rate of hospitalization, particularly in older patients suffering from chronic heart failure or chronic kidney disease. The high prevalence of anemia in chronic kidney disease is explained by a combination of erythropoietin and iron deficiency. This review summarizes the recommendations of the iron symposium at the 2010 German Geriatric Society Meeting in Potsdam, Germany. It intends to provide current information on prevalence, diagnostic work-up, and therapeutic options for anemia in the rapidly growing group of elderly patients.

摘要

老年患者贫血的患病率很高。在不同患者群体中存在一定差异,贫血患病率可达40%。贫血本身并非一种与年龄相关的疾病,而是一种具有多因素成因和高风险潜力的症状。它直接影响死亡率、发病率和住院率,尤其是在患有慢性心力衰竭或慢性肾病的老年患者中。慢性肾病中贫血的高患病率是由促红细胞生成素和铁缺乏共同导致的。本综述总结了2010年在德国波茨坦举行的德国老年医学会会议上铁专题研讨会的建议。旨在为快速增长的老年患者群体中的贫血患病率、诊断检查和治疗选择提供最新信息。

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引用本文的文献

1
[The geriatric syndrome of anemia-Summary of the symposium of the working group anemia during the annual meeting of the German Geriatric Society 2018 in Cologne, Germany].[老年贫血综合征——2018年德国老年医学会年会在德国科隆举行的贫血工作组研讨会总结]
Z Gerontol Geriatr. 2019 Jul;52(4):370-376. doi: 10.1007/s00391-019-01545-z. Epub 2019 Apr 23.
2
[Anemia in the aged - a geriatric syndrome? : Second position paper on anemia in the aged by the working group anemia of the German Geriatric Society].[老年人贫血——一种老年综合征?:德国老年医学会贫血工作组关于老年人贫血的第二篇立场文件]
Z Gerontol Geriatr. 2018 Dec;51(8):921-923. doi: 10.1007/s00391-018-1457-x. Epub 2018 Oct 4.
3

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缺铁性心力衰竭患者的羧基麦芽糖铁。
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Anemia of chronic disease (anemia of inflammation).慢性病贫血(炎症性贫血)
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Serum hepcidin-20 is elevated during the acute phase of myocardial infarction.血清铁调素-20在心肌梗死急性期升高。
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Hepcidin as a predictor of response to epoetin therapy in anemic cancer patients.铁调素作为贫血癌症患者对促红细胞生成素治疗反应的预测指标。
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Hepcidin-induced internalization of ferroportin requires binding and cooperative interaction with Jak2.铁调素诱导的铁转运蛋白内化需要与Jak2结合并协同相互作用。
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