缺氧标志物在软组织肉瘤中的预后影响。
Prognostic impacts of hypoxic markers in soft tissue sarcoma.
作者信息
Smeland Eivind, Kilvaer Thomas K, Sorbye Sveinung, Valkov Andrej, Andersen Sigve, Bremnes Roy M, Busund Lill-Tove, Donnem Tom
机构信息
Institute of Clinical Medicine, University of Tromso, 9037 Tromso, Norway.
出版信息
Sarcoma. 2012;2012:541650. doi: 10.1155/2012/541650. Epub 2012 Feb 20.
Background. We aimed to explore the prognostic impact of the hypoxia-induced factors (HIFαs) 1 and 2, the metabolic HIF-regulated glucose transporter GLUT-1, and carbonic anhydrase IX (CAIX) in non-gastrointestinal stromal tumor soft tissue sarcomas (non-GIST STS). Methods. Duplicate cores with viable tumor tissue from 206 patients with non-GIST STS were obtained and tissue microarrays were constructed. Immunohistochemistry (IHC) was used to evaluate expression of hypoxic markers. Results. In univariate analyses, GLUT-1 (P < 0.001) and HIF-2α (P = 0.032) expression correlated significantly with a poor disease-specific survival (DSS). In the multivariate analysis, however, only high expression of GLUT-1 (HR 1.7, CI 95% 1.1-2.7, P = 0.021) was a significant independent prognostic indicator of poor DSS. Conclusion. GLUT-1 is a significant independent negative prognostic factor in non-GIST STS.
背景。我们旨在探讨缺氧诱导因子（HIFαs）1和2、代谢性HIF调节的葡萄糖转运蛋白GLUT-1以及碳酸酐酶IX（CAIX）在非胃肠道间质瘤软组织肉瘤（非GIST STS）中的预后影响。方法。获取206例非GIST STS患者含有存活肿瘤组织的重复组织芯，并构建组织微阵列。采用免疫组织化学（IHC）评估缺氧标志物的表达。结果。在单因素分析中，GLUT-1（P < 0.001）和HIF-2α（P = 0.032）的表达与较差的疾病特异性生存（DSS）显著相关。然而，在多因素分析中，只有GLUT-1的高表达（HR 1.7，CI 95% 1.1 - 2.7，P = 0.021）是DSS较差的显著独立预后指标。结论。GLUT-1是非GIST STS中一个显著的独立阴性预后因素。
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