Ibsen Michael, Wiis Jørgen, Waldau Tina, Perner Anders
Intensive CareUnit 4131, University of Copenhagen, Rigshospitalet, Blegdamsvej 9, 2100 Copenhagen, Denmark.
Crit Care Res Pract. 2012;2012:504096. doi: 10.1155/2012/504096. Epub 2012 Feb 22.
In a recent study we found no difference in the concentrations of luminal lactate in the rectum between nonsurvivors and survivors in early septic shock (<24 h). This study was initiated to investigate if there are any changes in the concentrations of luminal lactate in the rectum during the first 3 days of septic shock and possible differences between nonsurvivors and survivors. Methods. We studied 22 patients with septic shock in this observational study. Six to 24 h after the onset of septic shock the concentration of lactate in the rectal lumen was estimated by 4 h equilibrium dialysis (day 1). The rectal dialysis was repeated on day 2 and day 3. Results. The concentration of lactate in the rectal lumen did not change over the 3 days in neither nonsurvivors nor survivors. Rectal luminal and arterial lactate concentrations were not different. Conclusion. There was no change in the concentration of lactate in the rectal lumen over time in patients with septic shock. Also, there was no difference between nonsurvivors and survivors.
在最近一项研究中，我们发现早期感染性休克（<24小时）患者中，非幸存者与幸存者直肠腔内乳酸浓度并无差异。开展本研究旨在调查感染性休克最初3天内直肠腔内乳酸浓度是否有任何变化，以及非幸存者与幸存者之间是否存在可能的差异。方法。在这项观察性研究中，我们对22例感染性休克患者进行了研究。感染性休克发作后6至24小时，通过4小时平衡透析法（第1天）估算直肠腔内乳酸浓度。在第2天和第3天重复进行直肠透析。结果。非幸存者和幸存者在3天内直肠腔内乳酸浓度均未发生变化。直肠腔内和动脉血乳酸浓度无差异。结论。感染性休克患者直肠腔内乳酸浓度不会随时间变化。此外，非幸存者与幸存者之间也无差异。
