Department of Therapeutics and Pharmacology, The Queen's University, Belfast, Northern Ireland.
Br J Clin Pharmacol. 1974 Feb;1(1):19-26. doi: 10.1111/j.1365-2125.1974.tb00201.x.
1 The administration of 0.5 mg glyceryl trinitrate by chewing and keeping under the tongue increased heart rate in normal subjects in the supine and erect posture. 2 There was no significant difference between the responses in the same subject on repeated administration of glyceryl trinitrate on different days but there was a significant difference between the responses in different subjects. 3 The oral administration of practolol and propranolol reduced the responses to glyceryl trinitrate. The two drugs progressively reduced the increase in heart rate produced by glyceryl trinitrate; there was no significant difference between their effects. Propranolol produced a significantly greater reduction than practolol in the maximum heart rate that was produced by glyceryl trinitrate. 4 The administration of practolol (300 mg) twice daily by mouth to patients after an acute episode of ischaemic heart disease significantly reduced the increases in heart rate produced by standing and by glyceryl trinitrate in comparison to the responses in similar patients receiving a placebo.
舌下含服 0.5 毫克硝化甘油可使仰卧和直立的正常受试者的心率加快。
同一受试者在不同日期重复给予硝化甘油时，其反应无显著差异，但不同受试者之间的反应有显著差异。
口服普萘洛尔和心得安可降低硝化甘油的反应。这两种药物逐渐减少硝化甘油引起的心率增加；它们的作用没有显著差异。与心得安相比，普萘洛尔在硝化甘油引起的最大心率方面的降低更为显著。
急性缺血性心脏病发作后，患者每天口服普萘洛尔（300 毫克）两次，与接受安慰剂的类似患者的反应相比，可显著降低站立和硝化甘油引起的心率增加。
