Department of Therapeutics and Pharmacology, The Queen's University of Belfast, and The Ulster Hospital, Dundonald, Belfast.
Br J Clin Pharmacol. 1974 Apr;1(2):93-8. doi: 10.1111/j.1365-2125.1974.tb00216.x.
1 Intravenous propranolol and practolol both reduced resting supine heart rate in patients with hyperthyroidism. Propranolol produced a significantly greater reduction than practolol, which did not have a dose-dependent effect. 2 The effect of these drugs on resting heart rate was much less than their effect on the tachycardias produced both by severe exercise and by standing upright in hyperthyroid patients. Propranolol again produced a significantly greater reduction than practolol in each situation, but practolol did have a dose dependent effect on exercise heart rate. 3 The percentage reduction of standing tachycardia produced by the two drugs appeared to parallel closely the reduction in exercise tachycardia. 4 It is concluded that a simple and convenient way of assessing the activity of β-adrenoceptor blocking drugs in hyperthyroid patients would be to measure their effect on the tachycardia induced by standing. Their effect on resting heart rate should not be used. 5 Practolol may be useful in the management of hyperthyroidism in patients in whom propranolol and similar non-selective β-adrenoceptor blocking drugs are contraindicated.
静脉注射普萘洛尔和普拉洛尔均可降低甲状腺功能亢进患者的静息仰卧心率。普萘洛尔的降低幅度明显大于普拉洛尔，后者没有剂量依赖性。
这些药物对静息心率的影响远小于它们对甲状腺功能亢进患者剧烈运动和直立时产生的心动过速的影响。普萘洛尔再次在每种情况下产生比普拉洛尔更大的降低幅度，但普拉洛尔对运动时的心率确实有剂量依赖性。
两种药物对站立性心动过速的降低百分比似乎与运动性心动过速的降低密切相关。
结论：评估β-肾上腺素能受体阻滞剂在甲状腺功能亢进患者中的活性的一种简单方便的方法是测量它们对站立引起的心动过速的影响。不应使用它们对静息心率的影响。
普拉洛尔可能对不能使用普萘洛尔和类似非选择性β-肾上腺素能受体阻滞剂的甲状腺功能亢进患者的治疗有用。
