不同雾化器（有和无间歇性正压通气）对沙丁胺醇吸收和代谢的影响。
The effect of different nebulizers with and without intermittent positive pressure breathing on the absorption and metabolism of salbutamol.
机构信息
Asthma Research Council Clinical Pharmacology Unit, Department of Medicine, Cardiothoracic Institute, Brompton, London.
出版信息
Br J Clin Pharmacol. 1974 Aug;1(4):295-300. doi: 10.1111/j.1365-2125.1974.tb00256.x.
1 The absorption and metabolism of [(3)H]-salbutamol have been studied to assess whether intermittent positive pressure breathing (IPPB) or a particular nebulizer have any advantages in delivering bronchodilator drugs to asthmatic patients. 2 [(3)H]-salbutamol (10 mg) was given to asthmatic patients from either the Bird Mark 7 ventilator without intermittent positive pressure, the Bird micronebulizer attached to an electric air compressor, or the Wright's nebulizer attached to the same compressor. 3 All patients showed a high early plasma level of radioactivity due mainly to free salbutamol. This pattern suggests absorption from the lung and is similar to that seen after giving the drug from the Bird nebulizer using IPPB. 4 In all cases less than 20% of the original dose was absorbed by the patient. 5 Improvement in forced expiratory volume in one second (FEV(1)) was seen with all three treatments.
为评估间歇正压通气（IPPB）或特定雾化器在向哮喘患者输送支气管扩张药物方面是否具有优势，对[(3)H]-沙丁胺醇的吸收和代谢进行了研究。
从无间歇正压的 Bird Mark 7 呼吸机、连接电动空气压缩机的 Bird 微型雾化器或连接同一压缩机的 Wright 雾化器，向哮喘患者给予[(3)H]-沙丁胺醇（10 mg）。
所有患者的早期血浆放射性水平均较高，主要是由于游离沙丁胺醇。这种模式提示来自肺部的吸收，与使用 IPPB 从 Bird 雾化器给予药物后观察到的情况相似。
在所有情况下，患者吸收的原始剂量均小于 20%。
三种治疗方法均能改善一秒用力呼气量（FEV(1)）。
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