Lilly Laboratory for Clinical Research, 960 Locke Street, Indianapolis, Indiana, U.S.A.
Br J Clin Pharmacol. 1974 Oct;1(5):371-4. doi: 10.1111/j.1365-2125.1974.tb00271.x.
1 The effect of repeated administration of phenobarbitone on the plasma disposition of fenoprofen (±-2-(3-phenoxyphenyl) propionic acid) was investigated in rats and man. 2 The plasma elimination rate constants increased significantly and the rats excreted proportionately more metabolized fenoprofen in the urine. These findings are consistent with an increase in the rate of metabolism of fenoprofen. 3 This interaction between phenobarbitone (and presumably other inducers of drug metabolizing enzymes) and fenoprofen should be considered when evaluating the clinical usefulness of fenoprofen.
重复给予苯巴比妥对人体和大鼠体内芬布芬（±-2-(3-苯氧苯基）丙酸）的血浆处置的影响进行了研究。
血浆消除速率常数显著增加，大鼠尿液中代谢的芬布芬比例增加。这些发现与芬布芬代谢率的增加一致。
在评估芬布芬的临床用途时，应考虑苯巴比妥（以及可能其他药物代谢酶诱导剂）与芬布芬之间的这种相互作用。
