多虑平对甲喹酮在人体内吸收的影响。
The influence of diphenhydramine on the absorption of methaqualone in man.
机构信息
Department of Pharmacy, Queen Elizabeth Hospital, Birmingham.
出版信息
Br J Clin Pharmacol. 1974 Jun;1(3):259-64. doi: 10.1111/j.1365-2125.1974.tb00247.x.
1 The effects of diphenhydramine on the buccal absorption, in vivo absorption and the in vitro dissolution of methaqualone have been studied. 2 Diphenhydramine significantly reduced the buccal absorption of methaqualone and the effect was dose and pH dependent. In vivo, diphenhydramine did not alter the rate of absorption or the distribution of methaqualone in blood. In vitro, the presence of diphenhydramine increased the rate of dissolution of methaqualone and the effect was more marked when the particle size was small. 3 The reasons for and the implications of these apparently contradictory results are discussed and it is concluded that any increased efficacy resulting from combining diphenhydramine with methaqualone cannot be due to increased plasma drug levels.
研究了苯海拉明对二甲喹酮颊部吸收、体内吸收和体外溶解的影响。
苯海拉明显著降低了二甲喹酮的颊部吸收，且这种作用具有剂量和 pH 值依赖性。在体内，苯海拉明并未改变二甲喹酮的吸收速率或在血液中的分布。在体外，苯海拉明的存在增加了二甲喹酮的溶解速率，且当粒径较小时，效果更为明显。
讨论了这些明显矛盾结果的原因和意义，并得出结论，将苯海拉明与二甲喹酮联合使用所产生的任何疗效增加都不能归因于血浆药物水平的增加。
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