吲哚与氧杂丙二烯阳离子加成，可方便地得到α-吲哚羰基化合物。
Addition of indoles to oxyallyl cations for facile access to α-indole carbonyl compounds.
机构信息
Division of Chemistry & Biological Chemistry, School of Physical & Mathematical Sciences, Nanyang Technological University, Singapore 637371, Singapore.
出版信息
Org Lett. 2012 Apr 6;14(7):1922-5. doi: 10.1021/ol300591z. Epub 2012 Mar 28.
PMID:22455439
Abstract
A direct coupling of unprotected indoles and α-halo ketones via in situ generated oxyallyl cation intermediates is described. The reactions efficiently afford α-indole carbonyl compounds with good to quantitative yields.
摘要
描述了一种通过原位生成的氧杂丙烯阳离子中间体将未保护的吲哚和α-卤代酮直接偶联的方法。该反应高效地提供了α-吲哚羰基化合物，产率良好至定量。
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