Rongioletti Franco, Pavesi Alessandra, Carli Carla, Parodi Aurora, Fiocca Roberto
Section of Dermatology, DISSAL, DISC, University of Genova, Genoa, Italy.
Am J Dermatopathol. 2012 Aug;34(6):653-7. doi: 10.1097/DAD.0b013e3182447f73.
Tumoral or nodular melanosis is considered as a rare manifestation of a completely regressed melanoma whose histopathological features include confluent dermal nodular aggregates of heavily melanized polygonal cells consistent with melanophages. Tumoral melanosis involving also lymph node is an even rarer event that has been reported only twice in the literature. We report a case of lymph node melanosis in the sentinel lymph node draining from a primary cutaneous lesion combining a dermal tumoral melanosis consistent with a complete regressed melanoma associated with a residual part of a deep congenital nevus. We discuss the histopathological diagnosis of our primary cutaneous lesion and the sentinel lymph node microscopic findings, compare our case with the previous ones, and discuss the possible prognostic and therapeutic implications.
肿瘤性或结节性黑变病被认为是完全消退的黑色素瘤的一种罕见表现，其组织病理学特征包括真皮内结节状聚集的大量黑素化多边形细胞，与噬黑素细胞一致。累及淋巴结的肿瘤性黑变病是一种更为罕见的情况，文献中仅报道过两例。我们报告一例前哨淋巴结的淋巴结黑变病，该前哨淋巴结引流自原发性皮肤病变，合并有与完全消退的黑色素瘤一致的真皮肿瘤性黑变病，且与深部先天性痣的残留部分相关。我们讨论了原发性皮肤病变的组织病理学诊断和前哨淋巴结的显微镜检查结果，将我们的病例与之前的病例进行了比较，并讨论了可能的预后和治疗意义。
