Malafronte Patrick, Sorrells Timothy
Department of Pathology and Laboratory Services, National Naval Medical Center, 8901 Wisconsin Ave, Bethesda, MD 20889-5600, USA.
Arch Pathol Lab Med. 2009 Aug;133(8):1332-4. doi: 10.5858/133.8.1332.
Tumoral or nodular melanosis in the skin is considered a variation of completely regressed melanoma, presenting clinically as a suspicious pigmented papule or nodule. Microscopically, the lesion consists of a nodular accumulation of heavily pigmented melanophages in the dermis, staining positive for immunohistochemical markers of histiocytic lineage (CD68) and negative for those of melanocytic lineage (S100, HMB-45, Melan-A). This process is rarely described in lymph nodes. We present a report of a patient with melanosis involving multiple lymph nodes of an axillary dissection, done for metastatic melanoma with an unknown primary, and discuss possible prognostic and treatment factors.
皮肤中的肿瘤性或结节性黑变病被认为是完全消退性黑色素瘤的一种变异，临床上表现为可疑的色素性丘疹或结节。在显微镜下，病变由真皮中大量色素沉着的噬黑素细胞结节状聚集组成，对组织细胞谱系的免疫组化标志物（CD68）染色呈阳性，而对黑素细胞谱系的标志物（S100、HMB-45、Melan-A）染色呈阴性。这个过程在淋巴结中很少被描述。我们报告了一名患者，其腋窝淋巴结清扫标本中有多个淋巴结发生黑变病，该清扫是针对原发灶不明的转移性黑色素瘤进行的，并讨论了可能的预后和治疗因素。
