Oertel-Knöchel Viola, Reinke Britta, Hornung Alexandra, Knöchel Christian, Matura Silke, Knopf Monika, Prvulovic David, O'Dwyer Laurence, Lindner Michael, Rau Alexandra, Hampel Harald, Haenschel Corinna, Linden David E J
Laboratory of Neuroscience, Department of Psychiatry, Psychosomatic Medicine and Psychotherapy, Goethe-University, Frankfurt/Main, Germany.
J Nerv Ment Dis. 2012 Apr;200(4):296-304. doi: 10.1097/NMD.0b013e31824ceef7.
This is the first study to combine psychometric and functional neuroimaging methods to study altered patterns of autobiographical memory in bipolar disorder (BD). All participants were interviewed with an expanded version of the Bielefelder Autobiographical Memory Inventory (Bielefelder Autobiographisches Gedächtnis Inventar 2004;Lisse: Swets and Zeitlinger). We then acquired functional magnetic resonance imaging data during a task of individually designed autobiographical recall. Compared with healthy controls, BD patients reported a stronger emotionality of autobiographical memories and more frequent recollections of autobiographical events during their everyday life. Furthermore, they failed to deactivate areas in the cuneus and lingual gyrus and showed decreased activation in the inferior frontal and precentral areas compared with the control group. More frequent intrusions from a person's past, which had a neural correlate in the lack of deactivation in some default mode network areas in BD patients, may contribute to manic or depressive symptoms.
这是第一项将心理测量和功能性神经成像方法相结合，以研究双相情感障碍（BD）患者自传体记忆模式改变的研究。所有参与者均接受了扩展版的比勒费尔德自传体记忆量表（Bielefelder Autobiographisches Gedächtnis Inventar 2004；利瑟：斯韦茨和蔡廷格出版社）的访谈。然后，我们在一项单独设计的自传体回忆任务中获取了功能磁共振成像数据。与健康对照组相比，BD患者报告的自传体记忆情感性更强，且在日常生活中对自传体事件的回忆更频繁。此外，与对照组相比，他们在楔叶和舌回区域未能实现去激活，且额下回和中央前回区域的激活减少。BD患者某些默认模式网络区域缺乏去激活，这与过去经历的更频繁侵入存在神经关联，可能会导致躁狂或抑郁症状。
