Allan H. Conney Laboratory for Anticancer Research, Guang Dong University of Technology, Guang Dong, 510006, China.
Org Biomol Chem. 2012 Jun 7;10(21):4164-71. doi: 10.1039/c2ob25160d. Epub 2012 Mar 29.
Described in this study is the ability of tetrabutylammonium salts (TBAX) to mediate an efficient mono- or di-demethylation removing one or two out of five aromatic methoxy methyl groups situated in similar chemical microenvironments in a H-bonded macrocyclic aromatic pentamer. These demethylations are found to be both chemo- and regioselective, and promoted by the H-bonding directed folding of the macrocyclic backbone.
本研究描述了四丁基铵盐（TBAX）介导有效单脱甲基或双脱甲基的能力，可将位于氢键合大环芳香五聚体中相似化学微环境中的五个芳氧基甲基中的一个或两个脱除。这些脱甲基反应具有化学和区域选择性，并且受到大环骨架的氢键导向折叠的促进。
