Department of Environmental Toxicology, University of California-Davis, One Shields Avenue, Davis, CA 95616, USA.
Bull Environ Contam Toxicol. 2012 Jun;88(6):1038-42. doi: 10.1007/s00128-012-0612-0. Epub 2012 Mar 29.
This study was conducted to evaluate the effect of molinate on retinoids homeostasis in rat testis. Molinate was administrated to male Sprague-Dawley rats (200 mg kg(-1) in corn oil, ip). Retinoid measurements were made at 6, 12, 48 and 168 h time points after administration. Testis levels of retinoic acid decreased (32 %) in a statistically significant manner at the 12 and 48 h time points. However, retinol and retinaldehyde were not significantly affected by molinate. These results suggest that molinate affects retinoic acid synthesis in testis and could contribute to understanding the molecular mechanism of molinate involved testicular toxicity.
本研究旨在评估灭草隆对大鼠睾丸类视黄醇稳态的影响。灭草隆以玉米油（200mg/kg，ip）给予雄性 Sprague-Dawley 大鼠。在给药后 6、12、48 和 168 小时测量类视黄醇水平。在 12 和 48 小时时，睾丸中视黄酸水平显著降低（32%）。然而，灭草隆对视黄醇和视黄醛没有显著影响。这些结果表明，灭草隆影响睾丸中视黄酸的合成，这可能有助于理解灭草隆引起睾丸毒性的分子机制。
