The role of ATM in response to metformin treatment and activation of AMPK.
作者信息
Yee Sook Wah, Chen Ligong, Giacomini Kathleen M
出版信息
Nat Genet. 2012 Mar 28;44(4):359-60. doi: 10.1038/ng.2236.
Abstract
摘要
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The role of ATM in response to metformin treatment and activation of AMPK.ATM在应对二甲双胍治疗及激活AMPK中的作用。
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The role of ATM in response to metformin treatment and activation of AMPK.ATM在应对二甲双胍治疗及激活AMPK中的作用。
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Metformin activates an ataxia telangiectasia mutated (ATM)/Chk2-regulated DNA damage-like response.二甲双胍激活一种由共济失调毛细血管扩张症突变基因（ATM）/Chk2调节的类似DNA损伤反应。
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Role of organic cation transporter 3 (SLC22A3) and its missense variants in the pharmacologic action of metformin.有机阳离子转运体 3（SLC22A3）及其错义变异体在二甲双胍药理作用中的作用。
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Ionizing radiation activates AMP-activated kinase (AMPK): a target for radiosensitization of human cancer cells.电离辐射激活 AMP 激活的蛋白激酶（AMPK）：提高人类癌细胞放射敏感性的靶点。
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Metformin inhibits hepatic gluconeogenesis in mice independently of the LKB1/AMPK pathway via a decrease in hepatic energy state.二甲双胍通过降低肝内能量状态，独立于 LKB1/AMPK 途径抑制小鼠的肝糖异生。
J Clin Invest. 2010 Jul;120(7):2355-69. doi: 10.1172/JCI40671. Epub 2010 Jun 23.
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Genotype-dependent effects of inhibitors of the organic cation transporter, OCT1: predictions of metformin interactions.有机阳离子转运蛋白 OCT1 抑制剂的基因型依赖性效应：预测二甲双胍的相互作用。
Pharmacogenomics J. 2011 Dec;11(6):400-11. doi: 10.1038/tpj.2010.54. Epub 2010 Jun 22.
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Etoposide induces ATM-dependent mitochondrial biogenesis through AMPK activation.依托泊苷通过激活AMPK诱导依赖ATM的线粒体生物合成。
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AICAR induces phosphorylation of AMPK in an ATM-dependent, LKB1-independent manner.AICAR以一种依赖ATM、不依赖LKB1的方式诱导AMPK磷酸化。
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Effect of genetic variation in the organic cation transporter 1 (OCT1) on metformin action.有机阳离子转运体1（OCT1）基因变异对二甲双胍作用的影响。
J Clin Invest. 2007 May;117(5):1422-31. doi: 10.1172/JCI30558.
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Activation of the ATM kinase by ionizing radiation and phosphorylation of p53.电离辐射激活 ATM 激酶以及 p53 的磷酸化。
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