Departments of Developmental Biology and Medicine, Oncology Division, Stanford University School of Medicine, Stanford, California, USA.
Nat Genet. 2012 Mar 28;44(4):363-4. doi: 10.1038/ng.2226.
Neuroendocrine cells, including those in the gut, have a vast array of functions. A new study shows that conditional inactivation of the gene encoding Foxo1 in mouse intestinal endocrine cells converts them into cells synthesizing and secreting insulin. Ectopic gut insulin production was sufficient to ameliorate glucose control in mice with conditional pancreatic β-cell loss and diabetes mellitus.
神经内分泌细胞，包括肠道中的细胞，具有广泛的功能。一项新的研究表明，条件性敲除小鼠肠道内分泌细胞中编码 Foxo1 的基因，可将其转化为合成和分泌胰岛素的细胞。异位肠道胰岛素的产生足以改善条件性胰岛β细胞缺失和糖尿病小鼠的葡萄糖控制。
